Probing demyelination and remyelination of the cuprizone mouse model using multimodality MRI.

Probing demyelination and remyelination of the cuprizone mouse model using multimodality MRI.

Publication date: Apr 22, 2019

Various studies by MRI exhibit that the corpus callosum (CC) is the most vulnerable to cuprizone administration, detecting the demyelination and remyelination process using different MRI parameters are, however, lacking.

To investigate the sensitivity of multiparametric MRI both in vivo and ex vivo for demyelination and remyelination.

Prospective.

A cuprizone mice model with an age-matched control group (n = 5), 4-week cuprizone exposure group followed by 9-week on a normal diet (n = 6), and a 13-week cuprizone exposure group (n = 6).

3D gradient recalled echo, T -weighted, and diffusion tensor imaging (DTI) at 7.0T and 9.4T.

Quantification of DTI metrics, quantitative susceptibility mapping (QSM), and T -weighted imaging intensity in major white matter bundles.

Nonparametric permutation tests were used with a cluster-forming threshold as 3.09 (equivalent to P = 0.001), and the significant level as P = 0.05 with family-wise correction.

In vivo susceptibility values increased from -11.7 to -0.7 ppb (P

QSM is sensitive to the demyelination process of cuprizone exposure, which can be a complementary technique to conventional T -weighted images and DTI metrics.

2 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019.

Wang, N., Zhuang, J., Wei, H., Dibb, R., Qi, Y., and Liu, C. Probing demyelination and remyelination of the cuprizone mouse model using multimodality MRI. 17798. 2019 J Magn Reson Imaging.

Concepts Keywords
3D MRI
Anterior Commissure DTI
Control Group Tensor
Corpus Callosum QSM
Demyelination Demyelinating disease
Diffusion Tensor Imaging MRI sequence
DTI Natural sciences
Gradient Diffusion MRI
In Vivo Quantitative susceptibility mapping
MRI Physical sciences
Permutation Physics
Ppb Magnetic resonance imaging
Vivo MS
Voxel Demyelination
White Matter Week cuprizone exposure
Control
Weighted imaging intensity

Semantics

Type Source Name
disease DOID multiple sclerosis
disease MESH multiple sclerosis
drug DRUGBANK Quinine
drug DRUGBANK Flunarizine
gene UNIPROT CYREN
disease MESH demyelination

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