Publication date: Apr 22, 2019
Various studies by MRI exhibit that the corpus callosum (CC) is the most vulnerable to cuprizone administration, detecting the demyelination and remyelination process using different MRI parameters are, however, lacking.
To investigate the sensitivity of multiparametric MRI both in vivo and ex vivo for demyelination and remyelination.
A cuprizone mice model with an age-matched control group (n = 5), 4-week cuprizone exposure group followed by 9-week on a normal diet (n = 6), and a 13-week cuprizone exposure group (n = 6).
3D gradient recalled echo, T -weighted, and diffusion tensor imaging (DTI) at 7.0T and 9.4T.
Quantification of DTI metrics, quantitative susceptibility mapping (QSM), and T -weighted imaging intensity in major white matter bundles.
Nonparametric permutation tests were used with a cluster-forming threshold as 3.09 (equivalent to P = 0.001), and the significant level as P = 0.05 with family-wise correction.
In vivo susceptibility values increased from -11.7 to -0.7 ppb (P
QSM is sensitive to the demyelination process of cuprizone exposure, which can be a complementary technique to conventional T -weighted images and DTI metrics.
2 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019.
Wang, N., Zhuang, J., Wei, H., Dibb, R., Qi, Y., and Liu, C. Probing demyelination and remyelination of the cuprizone mouse model using multimodality MRI. 17798. 2019 J Magn Reson Imaging.
- Magnetic resonance elastography of brain: Comparison between anisotropic and isotropic stiffness and its correlation to age.
- Evidence of early microstructural white matter abnormalities in multiple sclerosis from multi-shell diffusion MRI.
- Pathological changes in mice with long term cuprizone administration.