Blocking BRAF ubiquitination may be an effective treatment approach in melanoma

Blocking BRAF ubiquitination may be an effective treatment approach in melanoma

Publication date: Apr 25, 2019

Scientists have known that BRAF becomes activated by growth factors and subsequently stimulates downstream proteins that promote cancer cell growth, invasion and survival.

They found that pro-inflammatory cytokines released from immune cells stimulate the protein ITCH to modify BRAF by ubiquitination.

This ubiquitination modification prevents BRAF from interacting with inhibitory proteins, thereby maintaining the activity of BRAF and allowing it to stimulate the downstream proteins that promote cancer growth and metastasis.

“Our study reveals a pivotal role for ITCH-mediated BRAF ubiquitination in coordinating the signals between cytokines and the MAPK pathway activation in melanoma cells.

Concepts Keywords
Addiction Adam
BRAF Experiments melanoma
Cancer Melanomas
Cytokines Branches of biology
Growth Factors Medicine
Immune System Melanoma
Melanoma Medical specialties
Melanomas Cancer
Metastasis BRAF
Mice Oncogenes
Nature Communications Ubiquitin
Protein Inflammatory cytokine
Tumor Binimetinib
Tumorigenic Selumetinib
Ubiquitination Tumor
Wild Type Pro inflammatory cytokines

Semantics

Type Source Name
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
gene UNIPROT BRAF
disease MESH metastasis
gene UNIPROT ITCH
pathway BSID Immune System
disease MESH DNA damage
pathway BSID Protein Modifications
disease DOID Skin Cancer
disease MESH Skin Cancer
disease DOID cancer
disease MESH cancer
disease MESH development

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