Efficacy and Safety Study of Niraparib in Melanoma With Genetic Homologous Recombination (HR) Mutation

Efficacy and Safety Study of Niraparib in Melanoma With Genetic Homologous Recombination (HR) Mutation

Publication date: Apr 24, 2019

This open-label phase II trial studies how well niraparib works in treating patients with advanced, metastatic melanoma with the homologous recombination (HR) pathway gene mutation / alteration. Niraparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. The trial is designed to assess the efficacy and safety of niraparib in patients with HR mutation/ alteration whose disease progressed on prior immunotherapy and/or BRAF-targeting therapy.

Concepts Keywords
Acute Myeloid Leukemia Tumor
ATM Melanoma
ATR GBRCAmut tumors
BER Growth tumor
Bone Marrow Brain metastasis
BRAF BRCA1 BRCA2 melanoma
Brain Radiation therapy
BRCA Mutation Immunotherapy
BRCA1 Investigational therapy
BRCA2 Radiotherapy
California Major surgery
CHEK2 Branches of biology
Cytotoxic DNA repair
Genetic Breast cancer
Genetic Mutation Tumor markers
Germline Tumor suppressor genes
Homologous Recombination RTT
Immunocompromised PARP inhibitor
Immunotherapy BRCA1
Leptomeningeal Targeted therapy
Melanoma Homologous recombination
Metastatic Radiation
Mutation Recombination
Myelodysplastic Syndrome ATM
NHEJ
PARP
Protocol
RAD51
Radiation Therapy
Radiotherapy
Somatic
Steroid
Targeted Therapy
Toxicity
Tumor

Semantics

Type Source Name
gene UNIPROT BAP1
gene UNIPROT RNF2
gene UNIPROT BRCA1
gene UNIPROT BARD1
gene UNIPROT MMAB
gene UNIPROT ATR
gene UNIPROT ANTXR1
gene UNIPROT ARID2
gene UNIPROT ATM
gene UNIPROT ARID1A
gene UNIPROT BRAF
disease MESH tumor
disease MESH growth
gene UNIPROT MAP6
pathway BSID Homologous Recombination
pathway BSID Homologous recombination
pathway BSID Melanoma
disease DOID Melanoma
drug DRUGBANK Niraparib
disease MESH Melanoma
gene UNIPROT MAGI1
gene UNIPROT MRPL36
gene UNIPROT BRIP1
gene UNIPROT CHEK2
disease DOID FANCD2
gene UNIPROT FANCD2
gene UNIPROT RAD50
gene UNIPROT RAD51
gene UNIPROT RAD54B
gene UNIPROT COL11A2
gene UNIPROT PARP1
disease MESH metastasis
disease DOID cancer
disease MESH myelodysplastic syndrome
disease DOID myelodysplastic syndrome
disease DOID MDS
gene UNIPROT SF3B1
gene UNIPROT YWHAE
gene UNIPROT TET2
gene UNIPROT PAFAH1B1
gene UNIPROT ASXL1
disease DOID acute myeloid leukemia
pathway BSID Acute myeloid leukemia

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