Concise Review: Precision Matchmaking: Induced Pluripotent Stem Cells Meet Cardio-Oncology.

Concise Review: Precision Matchmaking: Induced Pluripotent Stem Cells Meet Cardio-Oncology.

Publication date: Apr 24, 2019

As common chemotherapeutic agents are associated with an increased risk of acute and chronic cardiovascular complications, a new clinical discipline, cardio-oncology, has recently emerged. At the same time, the development of preclinical human stem cell-derived cardiovascular models holds promise as a more faithful platform to predict the cardiovascular toxicity of common cancer therapies and advance our understanding of the underlying mechanisms contributing to the cardiotoxicity. In this article, we review the recent advances in preclinical cancer-related cardiotoxicity testing, focusing on new technologies, such as human induced pluripotent stem cell-derived cardiomyocytes and tissue engineering. We further discuss some of the limitations of these technologies and present future directions. Stem Cells Translational Medicine 2019.

Nair, P., Prado, M., , Perea-Gil, and , Karakikes. Concise Review: Precision Matchmaking: Induced Pluripotent Stem Cells Meet Cardio-Oncology. 04519. 2019 Stem Cells Transl Med.

Concepts Keywords
Cancer Cancer
Cardiomyocytes Chemotherapy
Cardiotoxicity Chemotherapy
Cardiovascular Embryonic stem cell
Cardiovascular Toxicity Tissue engineering
Chemotherapeutic Agents Branches of biology
Matchmaking Life sciences
Oncology Stem cells
Stem Cell Induced stem cells
Tissue Engineering Biotechnology

Semantics

Type Source Name
disease DOID cancer
disease MESH cancer
disease MESH development
disease MESH complications

Original Article

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