Systems biology in inflammatory bowel diseases: on the way to precision medicine.

Systems biology in inflammatory bowel diseases: on the way to precision medicine.

Publication date: Dec 17, 2018

Inflammatory bowel diseases (IBD) are chronic and recurrent inflammatory disorders of the gastrointestinal tract. The elucidation of their etiopathology requires complex and multiple approaches. Systems biology has come to fulfill this need in approaching the pathogenetic mechanisms of IBD and its etiopathology, in a comprehensive way, by combining data from different scientific sources. In combination with bioinformatics and network medicine, it uses principles from computer science, mathematics, physics, chemistry, biology, medicine and computational tools to achieve its purposes. Systems biology utilizes scientific sources that provide data from omics studies (e.g., genomics, transcriptomics, etc.) and clinical observations, whose combined analysis leads to network formation and ultimately to a more integrative image of disease etiopathogenesis. In this review, we analyze the current literature on the methods and the tools utilized by systems biology in order to cover an innovative and exciting field: IBD-omics.

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Dovrolis, N., Filidou, E., and Kolios, G. Systems biology in inflammatory bowel diseases: on the way to precision medicine. 04528. 2018 Ann Gastroenterol (32):3.

Concepts Keywords
Bowel Transcriptomics
Chemistry Genomics
Computer Science Precision medicine
Gastrointestinal Tract Inflammatory bowel disease
Genomics IBD
Inflammatory Bowel Diseases Genomics
Inflammatory Disorders Medical specialties
Mathematics Autoimmune diseases
Omics Branches of biology
Pathogenetic Disorders
Physics
Precision Medicine
Transcriptomics

Semantics

Type Source Name
drug DRUGBANK Guanosine
disease MESH genetic diseases
disease DOID age related macular degeneration
disease MESH age related macular degeneration
gene UNIPROT REST
pathway BSID Immune System
gene UNIPROT TNFSF13
gene UNIPROT ANP32B
gene UNIPROT COL9A3
gene UNIPROT COMP
gene UNIPROT COL9A1
gene UNIPROT COL9A2
gene UNIPROT SCN8A
gene UNIPROT NFKBIZ
gene UNIPROT PDC
gene UNIPROT WDFY2
disease MESH inflammation
disease DOID obesity
disease MESH obesity
gene UNIPROT DEPP1
gene UNIPROT GOPC
disease DOID ulcerative colitis
disease MESH ulcerative colitis
disease MESH multiple
disease DOID IBD
disease MESH inflammatory bowel diseases

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