Cognitive Fatigue in Multiple Sclerosis: An Objective Approach to Diagnosis and Treatment by Transcranial Electrical Stimulation.

Cognitive Fatigue in Multiple Sclerosis: An Objective Approach to Diagnosis and Treatment by Transcranial Electrical Stimulation.

Publication date: May 02, 2019

Cognitive fatigue is one of the most frequent symptoms in multiple sclerosis (MS), associated with significant impairment in daily functioning and quality of life. Despite its clinical significance, progress in understanding and treating fatigue is still limited. This limitation is already caused by an inconsistent and heterogeneous terminology and assessment of fatigue. In this review, we integrate previous literature on fatigue and propose a unified schema aiming to clarify the fatigue taxonomy. With special focus on cognitive fatigue, we survey the significance of objective behavioral and electrophysiological fatigue parameters and discuss the controversial literature on the relationship between subjective and objective fatigue assessment. As MS-related cognitive fatigue drastically affects quality of life, the development of efficient therapeutic approaches for overcoming cognitive fatigue is of high clinical relevance. In this regard, the reliable and valid assessment of the individual fatigue level by objective parameters is essential for systematic treatment evaluation and optimization. Transcranial electrical stimulation (tES) may offer a unique opportunity to manipulate maladaptive neural activity underlying MS fatigue. Therefore, we discuss evidence for the therapeutic potential of tES on cognitive fatigue in people with MS.

Linnhoff, S., Fiene, M., Heinze, H.J., and Zaehle, T. Cognitive Fatigue in Multiple Sclerosis: An Objective Approach to Diagnosis and Treatment by Transcranial Electrical Stimulation. 17925. 2019 Brain Sci (9):5.

Concepts Keywords
Cognitive Cancer-related fatigue
Electrophysiological Multiple sclerosis
Fatigue Transcranial direct-current stimulation
Maladaptive Fatigue
Multiple Sclerosis Neurotechnology
Optimization Medical devices
Schema Electrotherapy
Sci Neurophysiology
Survey Neurostimulation
Taxonomy Branches of biology
Clinical medicine
Medicine
Related cognitive fatigue
MS
Subjective objective fatigue
Cognitive fatigue

Semantics

Type Source Name
disease MESH development
disease MESH Diagnosis
disease DOID Multiple Sclerosis
disease MESH Multiple Sclerosis

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