Nanotubes enable travel of Huntington’s protein

Nanotubes enable travel of Huntington’s protein

Publication date: May 11, 2019

JUPITER, Fla. –May 10, 2019–A toxic protein linked to Huntington’s disease can move from neuron to neuron through a nanotube tunnel whose construction is initiated by a protein called Rhes, say scientists at Scripps Research.

The finding, by Scripps Research neuroscientist Srinivasa Subramaniam, PhD, improves understanding of how and why this disease attacks and destroys certain brain cells.

“We are excited about this result because it may explain why the patient gets the disease in this area of the brain called the striatum,” says Subramaniam, an associate professor in the Department of Neuroscience at Scripps Research-Florida.

People with Huntington’s disease inherit a damaged protein that is somehow complicit in destroying brain cells.

They inserted the Huntington human disease protein into the mouse brain cells, tagged it with fluorescence and then watched as it crossed over and crawled up to enter the neighboring cell.

The Rhes protein exists in both mouse and human brains sick with Huntington’s disease.

In 2009 study, Subramaniam found that Rhes also alters the Huntington disease protein’s structure making it more toxic to brain cells.

Subramaniam’s group continues to investigate what other proteins may be helping with tunnel construction and if other disease proteins move along these membranous highways.

His laboratory is also developing ways to identify how the Huntington’s disease protein travels in the live brain.

Concepts Keywords
Alzheimer Disease
Brain Http
Brain Damage Brain
Bridge Neuron
Confocal Microscope Medical terminology
Degenerative Disease
Endosomes
Facebook
Florida
Fluorescence
Globe
Huntington
India
Lake Bridge
LinkedIn
Lysosomes
Memory
Microns
Mold
Molecular Mechanics
Motor Control
Neurodegenerative
Neuron
Neurons
Neuroscientist
Nonprofit
Parkinson
PhD
Protein
Stigma
Striatum
Tunnel
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Semantics

Type Source Name
disease MESH cancer
disease DOID cancer
gene UNIPROT MAGEE1
disease MESH Huntington disease
disease DOID Huntington disease
gene UNIPROT IMPACT
drug DRUGBANK Tropicamide
disease MESH death
disease DOID degenerative disease
gene UNIPROT RASD2
gene UNIPROT PDC

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