Tumor thickness, location of primary melanoma affects recurrence rates

Tumor thickness, location of primary melanoma affects recurrence rates

Publication date: May 11, 2019

Researchers suggest that approximately 13% of patients with a high-risk primary melanoma may develop recurrence within 2 years, and informed clinical follow-up should include understanding the patterns and risk factors of disease recurrence.

-Our findings that ulceration and many mitoses are important histopathologic features associated with higher rates of recurrence are consistent with other evidence,” Lean A. von Schuckmann, MBBS, MPH, of the population health department at QIMR Berghofer Medical Research Institute in Australia, and colleagues wrote.

Independent predictors of recurrence were head or neck site of primary tumor, ulceration, thickness and mitotic rate greater than 3/mm2 (HR = 2. 36; 95% CI, 1. 19-4. 71).

In this population with high-risk primary melanoma, 2-year disease-free survival was 95% for T1b tumors and 67% for T4b tumors, treated by wide local excision with or without sentinel node biopsy, according to the researchers.

Concepts Keywords
AJCC Breslow’s depth
Australia Medicine
Bone RTT
Histologic Melanoma
Histopathologic Cancer
HR 2 Men Melanoma
MBBS Survival tumor
Melanoma Head neck tumors
Mitoses T1b tumors
Mitotic Disease
NHMRC Risks melanoma
Parotid Glands Locoregional tumors
Primary Tumor T4b tumors
Queensland
Sentinel Node Biopsy
Thyroid
Tumor
Ulceration

Semantics

Type Source Name
drug DRUGBANK Tropicamide
disease MESH diagnosis
gene UNIPROT PNMA2
disease DOID Cancer
gene UNIPROT ELL
disease MESH men
drug DRUGBANK Methylphenidate
disease MESH risk factors
disease MESH Tumor
disease MESH recurrence
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma

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