Publication date: May 11, 2019
Researchers suggest that approximately 13% of patients with a high-risk primary melanoma may develop recurrence within 2 years, and informed clinical follow-up should include understanding the patterns and risk factors of disease recurrence.
-Our findings that ulceration and many mitoses are important histopathologic features associated with higher rates of recurrence are consistent with other evidence,” Lean A. von Schuckmann, MBBS, MPH, of the population health department at QIMR Berghofer Medical Research Institute in Australia, and colleagues wrote.
Independent predictors of recurrence were head or neck site of primary tumor, ulceration, thickness and mitotic rate greater than 3/mm2 (HR = 2. 36; 95% CI, 1. 19-4. 71).
In this population with high-risk primary melanoma, 2-year disease-free survival was 95% for T1b tumors and 67% for T4b tumors, treated by wide local excision with or without sentinel node biopsy, according to the researchers.
- Risk of Melanoma Recurrence After Diagnosis of a High-Risk Primary Tumor.
- Recurrence of Melanoma After a Negative Sentinel Node Biopsy: Predictors and Impact of Recurrence Site on Survival.
- Newly Published Independent, Prospective Study Reinforces Prognostic Accuracy of DecisionDx-Melanoma in Cutaneous Melanoma
- Wide local excision prior to sentinel lymph node biopsy for primary melanoma of the head and neck.
- Sentinel Lymph Node Biopsy and Complete Lymph Node Dissection for Melanoma.