Publication date: May 10, 2019
Tunneling nanotubes (TNT) are thin, membranous, tunnel-like cell-to-cell connections, but the mechanisms underlying their biogenesis or functional role remains obscure. Here, we report, Rhes, a brain-enriched GTPase/SUMO E3-like protein, induces the biogenesis of TNT-like cellular protrusions, “Rhes tunnels,” through which Rhes moves from cell to cell and transports Huntington disease (HD) protein, the poly-Q expanded mutant Huntingtin (mHTT). The formation of TNT-like Rhes tunnels requires the Rhes’s serine 33, C-terminal CAAX, and a SUMO E3-like domain. Electron microscopy analysis revealed that TNT-like Rhes tunnels appear continuous, cell-cell connections, and
Sharma, M. and Subramaniam, S. Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion. 06481. 2019 J Cell Biol.
|C Terminal||Tunneling nanotube|
|E3||Branches of biology|
- Nanotubes enable travel of Huntington’s protein
- Zinc-Finger Repressive Proteins Show Promise as Treatment for Huntington’s in Mouse Studies