Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion.

Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion.

Publication date: May 10, 2019

Tunneling nanotubes (TNT) are thin, membranous, tunnel-like cell-to-cell connections, but the mechanisms underlying their biogenesis or functional role remains obscure. Here, we report, Rhes, a brain-enriched GTPase/SUMO E3-like protein, induces the biogenesis of TNT-like cellular protrusions, “Rhes tunnels,” through which Rhes moves from cell to cell and transports Huntington disease (HD) protein, the poly-Q expanded mutant Huntingtin (mHTT). The formation of TNT-like Rhes tunnels requires the Rhes’s serine 33, C-terminal CAAX, and a SUMO E3-like domain. Electron microscopy analysis revealed that TNT-like Rhes tunnels appear continuous, cell-cell connections, and

Sharma, M. and Subramaniam, S. Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion. 06481. 2019 J Cell Biol.

Concepts Keywords
Biogenesis Huntingtin
Brain RASD2
C Terminal Tunneling nanotube
E3 Branches of biology
Electron Microscopy
GTPase
Huntingtin
Huntington
Mutant
Nanotubes
Protein
Serine
SUMO
TNT
Tunnel

Semantics

Type Source Name
drug DRUGBANK Serine
gene UNIPROT C16orf82
gene UNIPROT TNNT1
drug DRUGBANK Trinitrotoluene
disease DOID Huntington disease
disease MESH Huntington disease
gene UNIPROT RASD2

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