STIM Proteins and Glutamate Receptors in Neurons: Role in Neuronal Physiology and Neurodegenerative Diseases.

STIM Proteins and Glutamate Receptors in Neurons: Role in Neuronal Physiology and Neurodegenerative Diseases.

Publication date: May 09, 2019

Neuronal calcium (Ca) influx has long been ascribed mainly to voltage-gated Ca channels and glutamate receptor channels. Recent research has shown that it is also complemented by stromal interaction molecule (STIM) protein-mediated store-operated Ca entry (SOCE). SOCE is described as Ca flow into cells in response to the depletion of endoplasmic reticulum Ca stores. The present review summarizes recent studies that indicate a relationship between neuronal SOCE that is mediated by STIM1 and STIM2 proteins and glutamate receptors under both physiological and pathological conditions, such as neurodegenerative disorders. We present evidence that the dysregulation of neuronal SOCE and glutamate receptor activity are hallmarks of acute neurodegenerative diseases (e.g., traumatic brain injury and cerebral ischemia) and chronic neurodegenerative diseases (e.g., Alzheimer’s disease and Huntington’s disease). Emerging evidence indicates a role for STIM proteins and glutamate receptors in neuronal physiology and pathology, making them potential therapeutic targets.

Serwach, K. and Gruszczynska-Biegala, J. STIM Proteins and Glutamate Receptors in Neurons: Role in Neuronal Physiology and Neurodegenerative Diseases. 06480. 2019 Int J Mol Sci (20):9.

Concepts Keywords
Alzheimer NMDA receptor
Calcium Neuron
Cerebral Ischemia STIM1
Endoplasmic Reticulum Glutamate receptor
Glutamate Neurotransmitters
Huntington Branches of biology
Molecule Glutamate
Neurodegenerative Diseases STIM2
Neurodegenerative Disorders Neurodegenerative disorders
Pathology Acute neurodegenerative diseases
Physiology Chronic neurodegenerative diseases
Protein
Receptor
Receptors
Sci
STIM
STIM1
Stromal
Traumatic Brain Injury
Voltage

Semantics

Type Source Name
disease MESH cerebral ischemia
gene UNIPROT STIM2
gene UNIPROT STIM1
drug DRUGBANK Calcium
pathway BSID Neurodegenerative Diseases
disease MESH Neurodegenerative Diseases

Original Article

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