Incidence trends of conjunctival malignant melanoma in Canada.

Incidence trends of conjunctival malignant melanoma in Canada.

Publication date: May 11, 2019

Melanoma is the most common primary malignancy of the eye in adults. While the epidemiology of uveal melanoma has recently been described in Canada, little is known about the epidemiology and geographic distribution of patients with conjunctival melanoma (CM) in Canada.

We conducted a population-based study of CM incidence across all Canadian provinces and territories during 1992-2010 using two independent population-based registries.

190 patients were diagnosed with CM in Canada from 1992 to 2010. 55.3 % of these patients were men. The mean annual incidence rate of CM in Canada was 0.32 cases per million individuals (0.35 and 0.29 cases per million individuals for men and women, respectively). The incidence rates for Canadian provinces demonstrated that the eastern provinces of Nova Scotia and New Brunswick had higher age-adjusted incidence rates than the national average, with rates of 0.52 and 0.47 cases per million individuals per year, respectively.

This analysis demonstrates novel variations in CM incidence rates between different Canadian provinces. These results taken together with the data reported from the USA confirm the North-to-South geographic gradient of increasing CM incidence. This research highlights that the epidemiology of CM in North America is comparable to that of cutaneous malignant melanoma in contrast to the trends for uveal melanoma distribution.

Ghazawi, F.M., Darwich, R., Le, M., Jfri, A., Rahme, E., Burnier, J.V., Sasseville, D., Burnier, M.N., and , Litvinov. Incidence trends of conjunctival malignant melanoma in Canada. 22595. 2019 Br J Ophthalmol.

Concepts Keywords
Canada Health
Canadian RTT
CM Melanoma
Conjunctival Radiation
Epidemiology V conjunctival melanoma
Gradient Uveal melanoma
Incidence Radiation
Malignancy Incidence
Malignant Melanoma Uveal melanoma
Melanoma Epidemiology
North America Cancer
Nova Scotia Articles
Uveal Melanoma Neoplasms

Semantics

Type Source Name
drug DRUGBANK Flunarizine
gene UNIPROT ELL
disease MESH men
disease DOID conjunctival melanoma
disease DOID uveal melanoma
disease MESH uveal melanoma
disease MESH malignancy
pathway BSID Melanoma
disease DOID malignant melanoma
disease MESH malignant melanoma

Original Article

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