Mechanisms of Genomic Instability in Breast Cancer.

Mechanisms of Genomic Instability in Breast Cancer.

Publication date: May 08, 2019

Breast cancer is the most common cancer among women globally. Genomic instability (GI) refers to the increased tendency to accrue genomic alterations. It drives heterogeneity and is a hallmark of cancer. Genomic integrity is closely guarded by several mechanisms, including DNA damage checkpoints, the DNA repair machinery, and the mitotic checkpoint. Alterations in these surveillance mechanisms cause GI. In breast cancer, several pathways maintaining genomic integrity are distinctly altered, including some that have been successfully exploited for therapeutic targeting. In this review, we comprehensively discuss the recent advances on the mechanisms of GI in breast cancer, highlighting DNA repair defects and chromosome segregation errors during mitosis. We further review the clinical implications and therapeutic potential of targeting GI in the era of precision medicine.

Duijf, P.H.G., Nanayakkara, D., Nones, K., Srihari, S., Kalimutho, M., and Khanna, K.K. Mechanisms of Genomic Instability in Breast Cancer. 04588. 2019 Trends Mol Med.

Concepts Keywords
Breast Cancer Spindle checkpoint
Cancer Cell cycle checkpoint
Chromosome Segregation Aneuploidy
Genomic Instability Genome instability
Heterogeneity Chromosome instability
Mitosis Cytogenetics
Mitotic Checkpoint Cancer
Precision Medicine Cell cycle
Surveillance Chromosomes
Chromosomal abnormalities
Genetics
Branches of biology
Mechanisms breast cancer
Machinery

Semantics

Type Source Name
disease MESH chromosome instability
disease MESH aneuploidy
gene UNIPROT ERAL1
gene UNIPROT ESR1
disease MESH defects
pathway BSID DNA Repair
disease MESH DNA damage
disease DOID cancer
disease MESH cancer
pathway BSID Breast cancer
disease DOID Breast Cancer
disease MESH Breast Cancer
disease MESH Genomic Instability

Original Article

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