Speech difficulties in early de novo patients with Parkinson’s disease.

Speech difficulties in early de novo patients with Parkinson’s disease.

Publication date: May 07, 2019

Speech difficulties are a common debilitating feature of Parkinson’s disease and we aimed to investigate whether speech difficulties are associated with striatal dopaminergic deficits and faster disease progression.

Using the Parkinson’s Progression Markers Initiative database, 143 early de novo Parkinson’s disease patients with speech difficulties were identified and matched 1:1 with 143 Parkinson’s disease patients without speech difficulties for age, disease duration and motor symptom severity. We investigated differences in clinical features and striatal [I]FP-CIT single photon emission computed tomography (SPECT) uptake in Parkinson’s disease patients with and without speech difficulties. Cox proportional hazards analysis was carried out to investigate whether speech difficulties were predictive of a faster motor progression and cognitive decline.

Speech difficulties were more common in patients with an akinetic-rigid motor phenotype compared to those with a tremor-dominant phenotype. Parkinson’s disease patients with speech difficulties had lower resting tremor (P = 0.027), higher autonomic dysfunction (P = 0.034), increased daytime sleepiness (ESS; P = 0.048), and a higher prevalence of REM sleep behaviour disorder (RBD) symptoms (P = 0.007) compared to those without speech difficulties. Parkinson’s disease patients with speech difficulties had significantly lower [I]FP-CIT uptake in the striatum (P  0.10).

Speech difficulties are associated with greater autonomic dysfunction, sleep disturbances and striatal dopaminergic deficit, and can serve as a predictor of faster cognitive decline in early Parkinson’s disease.

Polychronis, S., Niccolini, F., Pagano, G., Yousaf, T., and Politis, M. Speech difficulties in early de novo patients with Parkinson’s disease. 20749. 2019 Parkinsonism Relat Disord.

Concepts Keywords
Autonomic Dysfunction Tomography
CIT Speech
Cognitive Striatum
Dopaminergic Parkinson
IFP Dementia
Parkinson Neuroscience
Parkinsonism Learning disabilities
Phenotype Cognitive disorders
RBD Aging-associated diseases
REM Sleep Psychiatry
Sleep Disturbances RTT
Sleepiness Psychiatric diagnosis
SPECT Brain
Striatal
Striatum
Symptom
Tremor

Semantics

Type Source Name
disease DOID ESS
disease MESH tremor
disease MESH cognitive decline
gene UNIPROT COX5A
gene UNIPROT COX8A
gene UNIPROT CPOX
gene UNIPROT DHDDS
gene UNIPROT CIT
drug DRUGBANK L-Citrulline
disease MESH disease progression

Original Article

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