Current insights into the epigenetic mechanisms of skin cancer.

Current insights into the epigenetic mechanisms of skin cancer.

Publication date: May 13, 2019

Skin cancer is a manifestation of tumors. The different types of skin cancer are named according to their source of tumor cells. Currently, there are three main types of skin cancer. They are squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and melanoma. Their epidemiological characteristics, clinical classifications and treatment methods are somewhat different. The epigenetic modifications are also different in these three types of skin cancer. Epigenetics is the change in gene expression and function and the generation of a heritable phenotype without changing the DNA sequence. The phenomenon of epigenetics involves a variety of processes, including the methylation of DNA and RNA, histone modifications, RNAi, and chromatin remodeling. Researchers have found that DNA, RNA, histone, and chromatin level modifications cause heritable changes in gene expression patterns. This review will introduce the role of epigenetics in skin cancer from the three following angles: DNA methylation, histone modifications and RNA methylation. This article is protected by copyright. All rights reserved.

Sang, Y. and Deng, Y. Current insights into the epigenetic mechanisms of skin cancer. 22598. 2019 Dermatol Ther.

Concepts Keywords
Basal Pharmacoepigenetics
Carcinoma Book:Epigenetics
Chromatin ATM serine/threonine kinase
Chromatin Remodeling Chromatin remodeling
DNA Epigenetics
Epidemiological Genetics
Epigenetic Branches of biology
Epigenetics Skin cancer
Heritable Skin manifestation tumors
Skin Cancer
Squamous Carcinoma


Type Source Name
pathway BSID Histone Modifications
pathway BSID Histone modifications
pathway BSID Methylation
pathway BSID Gene Expression
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
pathway BSID Basal cell carcinoma
disease DOID basal cell carcinoma
disease MESH basal cell carcinoma
disease DOID squamous cell carcinoma
disease MESH squamous cell carcinoma
disease MESH tumors
disease DOID skin cancer
disease MESH skin cancer

Original Article

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