Glial cells as therapeutic targets in progressive multiple sclerosis.

Glial cells as therapeutic targets in progressive multiple sclerosis.

Publication date: May 13, 2019

Multiple sclerosis is a serious demyelinating disease of the central nervous system (CNS) with treatments generally restricted to immunosuppression to reduce attack rate and for symptom management. Glial cells may be useful targets for future CNS regenerative therapies to reverse disease. Areas covered: In this review, the authors cover currently available multiple sclerosis treatments and examine potential upcoming therapies targeting glial cells. The potential for new therapeutic approaches in the treatment of progressive multiple sclerosis is examined. Expert opinion: Microglia, astrocytes, and oligodendrocytes are each promising targets for the disease-altering treatment of multiple sclerosis. Though challenging, the opportunities presented have great potential for CNS regeneration and further investigation of glial cells in therapy is warranted. Patient-specific combinatorial therapy targeting the three glial cell types is expected to be the future of MS treatment.

Wilbanks, B., Maher, L.J., and Rodriguez, M. Glial cells as therapeutic targets in progressive multiple sclerosis. 17982. 2019 Expert Rev Neurother.

Concepts Keywords
Astrocytes Polydendrocytes
Central Nervous System Remyelination
Combinatorial Brain disorders
Glial Oligodendrocyte
Glial Cells Myelin
Immunosuppression Multiple sclerosis
Microglia Neurology
Multiple Sclerosis Nervous system
Oligodendrocytes Organ systems
Progressive Glial cells
Symptom Branches of biology
Immunosuppression
Treatment multiple sclerosis

Semantics

Type Source Name
gene UNIPROT RXFP2
disease DOID demyelinating disease
disease MESH demyelinating disease
disease DOID multiple sclerosis
disease MESH multiple sclerosis

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