Publication date: May 14, 2019
The team of scientists has shown experimentally, for the first time, how mutations ultimately set off an anti-viral like inflammatory response in cells that leads to cell death and, over time, progressive neurological damage.
This study investigates the outcomes of a mutation linked to Huntington’s disease and 20 other neurodegenerative diseases, including some forms of motor neurone disease.
“The abnormal RNA is made from regions of repeated DNA sequences that are found in greater numbers in people affected with Huntington’s and some other neurodegenerative diseases. “
Professor Richards says there are existing drugs for other types of auto-inflammatory disease, which may prove to be effective in treating the symptoms of these diseases, by inhibiting the anti-viral inflammatory response.