Publication date: May 13, 2019
The latest revision of the McDonald criteria for the diagnosis of multiple sclerosis (MS) was published online in 2017. New features of the criteria, which were designed to facilitate earlier diagnosis of MS, include the recognition of oligoclonal bands in the cerebrospinal fluid as a possible marker of dissemination of MS pathology in time, the introduction of symptomatic lesions as a parameter to demonstrate spatial or temporal pathology dissemination, and the use of cortical lesions to demonstrate dissemination in space. In this Viewpoint, a panel of world-renowned MS specialists share their personal experiences of the new criteria to date.
Zipp, Frauke, Oh, Jiwon, Fragoso, Yara Dadalti., and Waubant, Emmanuelle. Implementing the 2017 McDonald criteria for the diagnosis of multiple sclerosis. 17992. 2019 Nature Reviews Neurology.
- Impact of the McDonald Criteria 2017 on Early Diagnosis of Relapsing-Remitting Multiple Sclerosis.
- Diagnosis of multiple sclerosis: revisions of the McDonald criteria 2017 – continuity and change.
- The clinical significance of single or double bands in cerebrospinal fluid isoelectric focusing. A retrospective study and systematic review.
- VA researchers develop biomarkers, blood test that shows MS patients in relapse