Linking Epigenomics With Prescription Opioid Abuse and High Impact Musculoskeletal Pain

Linking Epigenomics With Prescription Opioid Abuse and High Impact Musculoskeletal Pain

Publication date: May 13, 2019

Genetic variability from epigenetic modification of genes related to pain physiology and opioid pharmacodynamics may influence susceptibility to high-impact chronic musculoskeletal pain, opioid efficacy, and vulnerability to opioid abuse. Exploring the role of epigenomics and opioid addiction may improve understanding and treatment of these complex multifactorial conditions and, potentially, reduce their development.

Concepts Keywords
Chronic Pain Opioids
COMT RTT
Epigenetic Psychoactive drugs
Epigenomics Morphine
Florida Morphinans
Genetic Euphoriants
Genetic Variability Opioid use disorder
Methylated Addiction
Methylation Chronic pain
Musculoskeletal Μ-opioid receptor
Opioid Epigenomics
Opioid Addiction Pharmacodynamics
Opioids
OPRM1
Pain
Pharmacodynamics
Physiology
Promoter Region
Psychosocial
Spectrum

Semantics

Type Source Name
disease MESH Opioid Abuse
disease DOID Opioid Abuse
gene UNIPROT IMPACT
disease MESH Musculoskeletal Pain
disease MESH development
gene UNIPROT EHD1
gene UNIPROT NR4A2
gene UNIPROT ALG3
disease MESH Substance-Related Disorders

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