Measures of general and abdominal obesity and disability severity in a large population of people with multiple sclerosis.

Measures of general and abdominal obesity and disability severity in a large population of people with multiple sclerosis.

Publication date: May 13, 2019

Metabolic comorbidity is overrepresented in people with multiple sclerosis (MS) and is associated with adverse MS outcomes. Excess visceral adiposity, approximated using waist circumference (WC), is a risk factor for metabolic comorbidity and predicts poorer outcomes in other neurologic diseases.

To evaluate the association between WC and clinical and disease characteristics in people with MS.

North American Research Committee on MS (NARCOMS) registry participants reported height and weight (used to calculate body mass index (BMI)) and were mailed a tape measure with instructions to measure WC. We considered WC continuously and used cut-points derived from the abdominal obesity criteria for the metabolic syndrome (men: WC ⩾ 40 in; women: WC ⩾ 35 in). We assessed the association between WC and disability (Patient-Determined Disease Steps) and symptom severity (validated scales) using multivariable-adjusted multinomial models.

Of 6367 responders with MS, we included 5832 (92%). Of these, 3181 (55%) reported WC meeting criteria for the abdominal obesity component of metabolic syndrome. In multivariable models adjusting for overall obesity status, WC was associated with 47% increased odds of severe versus mild disability (odds ratio (OR): 1.47; 95% confidence interval (CI): 1.22-1.78).

Increased WC is associated with more severe disability, even after adjusting for overall obesity in this large cross-sectional survey.

Fitzgerald, K.C., Salter, A., Tyry, T., Fox, R.J., Cutter, G., and Marrie, R.A. Measures of general and abdominal obesity and disability severity in a large population of people with multiple sclerosis. 17991. 2019 Mult Scler.

Concepts Keywords
Abdominal Obesity Obesity-associated morbidity
Adiposity Metabolic syndrome
BMI Abdominal obesity
Body Mass Comorbidity
Comorbidity Bariatrics
Confidence Interval Diabetes
Cross Clinical medicine
Disability Medicine
Metabolic Syndrome Obesity
Multinomial Health
Multiple Sclerosis MS
Neurologic Diseases
Obesity
Odds Ratio
Risk Factor
Steps
Survey
Symptom

Semantics

Type Source Name
disease DOID obesity
disease MESH obesity
gene UNIPROT ELL
disease MESH men
disease MESH metabolic syndrome
gene UNIPROT FBN1
disease MESH risk factor
disease MESH comorbidity
disease DOID multiple sclerosis
disease MESH multiple sclerosis
gene UNIPROT LARGE1
disease MESH abdominal obesity

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