Repeated assessment of key clinical walking measures can induce confounding practice effects.

Repeated assessment of key clinical walking measures can induce confounding practice effects.

Publication date: May 13, 2019

Accurate functional outcome measures are critical for both clinical trials and routine patient assessments. Many functional outcomes improve with test repetition, a phenomenon that can confound the findings of longitudinal assessments. In this viewpoint, we tackle the poorly considered issue of practice effects in prevailing clinical walking tests based on current literature, while also presenting the original data from our own work, in which we investigated practice effects in the timed 25-foot walk (T25FW), timed-up and go (TUG), and 2-minute walk test (2MWT). In these tests, performed on 3 consecutive days in 10 patients with multiple sclerosis and 40 healthy controls, we observed significant practice effects in several established walking outcomes, including a 9.0% improvement in patients’ TUG performance ( p = 0.0146). Pre-training in these walking tests prior to baseline measurement may mitigate practice effects, thereby improving the accuracy and value of their repeated use in research and clinical settings.

Meyer, C., Killeen, T., L”orincz, L., Curt, A., Bolliger, M., Linnebank, M., Z”orner, B., and Filli, L. Repeated assessment of key clinical walking measures can induce confounding practice effects. 17985. 2019 Mult Scler.

Concepts Keywords
Clinical Trials Articles
Multiple Sclerosis Clinical trial
Multiple sclerosis
Health

Semantics

Type Source Name
disease MESH gait
disease DOID multiple sclerosis
disease MESH multiple sclerosis
gene UNIPROT ASPSCR1

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