Ten Years of Fentanyl-like Drugs: a Technical-analytical Review.

Ten Years of Fentanyl-like Drugs: a Technical-analytical Review.

Publication date: May 10, 2019

Synthetic opioids, such as fentanyl and its analogues, are a new public health warning. Clandestine laboratories produce drug analogues at a faster rate than these compounds can be controlled or scheduled by drug agencies. Detection requires specific testing and clinicians may be confronted with a sequence of severe issues concerning the diagnosis and management of these contemporary opioid overdoses. This paper deals with methods for biological sample treatment, as well as the methodologies of analysis that have been reported, in the last decade, in the field of fentanyl-like compounds. From this analysis, it emerges that the gold standard for the identification and quantification of 4-anilinopiperidines is LC-MS/MS, coupled with liquid-liquid or solid-phase extraction. In the end, the return to the scene of illicit fentanyls can be considered as a critical problem that can be tackled only with a global multidisciplinary approach.

Roda, G., Faggiani, F., Bolchi, C., Pallavicini, M., and Dei Cas, M. Ten Years of Fentanyl-like Drugs: a Technical-analytical Review. 03504. 2019 Anal Sci (35):5.

Concepts Keywords
Analytical Review Isobutyrylfentanyl
Fentanyl Orthofluorofentanyl
Gold Standard Fentanyl
Liquid Liquid Organic compounds
Opioid Synthetic opioids
Opioids Designer drugs
Scheduled Drug Piperidines
Sci Anilides
Chemical compounds
Psychoactive drugs


Type Source Name
drug DRUGBANK Gold
disease MESH diagnosis
drug DRUGBANK Fentanyl
drug DRUGBANK Pentaerythritol tetranitrate


Original Article

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