Application of temporary agglomeration of chitosan-coated nanoparticles for the treatment of lung metastasis of melanoma.

Application of temporary agglomeration of chitosan-coated nanoparticles for the treatment of lung metastasis of melanoma.

Publication date: May 15, 2019

Temporary association of chitosan (CS)-coated nanoparticles (NPs) including phloretin (Phl) in the blood stream can be applied to treat lung metastasis of melanoma. Phl was entrapped in poly(d,l-lactide-co-glycolide) (PLGA) NPs as an anticancer agent, whereas CS was decorated onto the outer surfaces of the Phl-loaded PLGA NPs (PLGA/Phl NPs). CS-coated PLGA/Phl NPs (CS-PLGA/Phl NPs) with mean hydrodynamic sizes of 342 nm, spherical shapes, unimodal size distribution, positive zeta potentials, and drug encapsulation efficiency larger than 90% were prepared. The presence of the CS layers in the outer surfaces of the CS-PLGA/Phl NPs was elucidated by X-ray photoelectron spectroscopy. Upon blending of the CS-PLGA/Phl NPs with serum albumin, microscale agglomerates formed and easily dissociated into individual NPs by applying external forces. A sustained Phl release from NPs and similar antiproliferation potential of the CS-PLGA/Phl NPs to that of Phl in melanoma (B16F10) cells were observed. After multiple dosing of developed NPs in mouse models with lung metastasis of melanoma, the CS-PLGA/Phl NPs group exhibited significantly lower lung weight and number of metastasis foci than the PLGA/Phl NPs group (p 

Lee, S.Y., Koo, J.S., Yang, M., and Cho, H.J. Application of temporary agglomeration of chitosan-coated nanoparticles for the treatment of lung metastasis of melanoma. 22604. 2019 J Colloid Interface Sci (544):

Concepts Keywords
Agglomeration Spectroscopy
Blood Nanoparticle
Chitosan PLGA
Colloid Copolymers
Encapsulation Phl melanoma B16F10
Foci
Glycolide
Hydrodynamic
Lung
Melanoma
Metastasis
Microscale
Nanoparticles
Photoelectron Spectroscopy
Sci
Serum Albumin
Unimodal
X Ray

Semantics

Type Source Name
disease MESH multiple
pathway BSID Release
drug DRUGBANK Human Serum Albumin
gene UNIPROT RAB35
gene UNIPROT SH3YL1
gene UNIPROT AP5Z1
gene UNIPROT PSMA5
gene UNIPROT BCR
gene UNIPROT NPS
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
disease MESH metastasis

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