Publication date: May 15, 2019
The HLA-DR15 extended haplotype HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 comprises the strongest genetic risk factor for multiple sclerosis (MS). The aim of this work was to investigate whether HLA-DR15 alleles were significantly associated with the susceptibility to MS familial forms (MSf) in an admixed Brazilian population.
Association analyses between DR15 and the clinical and demographic variables were made.
We have genotyped 25 familial cases. The DR15 was detected in 11/25 (44%) of them and in none of controls (P
da Silva Bernardes, M., Ant~ao Paiva, C.L., Ribeiro Paradela, E., Papais Alvarenga, M., Ferreira Pereira, F., Vasconcelos, C.C., and Papais Alvarenga, R.M. Familial multiple sclerosis in a Brazilian sample: Is HLA-DR15 involved in susceptibility to the disease? 18001. 2019 J Neuroimmunol (330):
|Genetic||MHC Class II|