Familial multiple sclerosis in a Brazilian sample: Is HLA-DR15 involved in susceptibility to the disease?

Familial multiple sclerosis in a Brazilian sample: Is HLA-DR15 involved in susceptibility to the disease?

Publication date: May 15, 2019

The HLA-DR15 extended haplotype HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 comprises the strongest genetic risk factor for multiple sclerosis (MS). The aim of this work was to investigate whether HLA-DR15 alleles were significantly associated with the susceptibility to MS familial forms (MSf) in an admixed Brazilian population.

Association analyses between DR15 and the clinical and demographic variables were made.

We have genotyped 25 familial cases. The DR15 was detected in 11/25 (44%) of them and in none of controls (P 

da Silva Bernardes, M., Ant~ao Paiva, C.L., Ribeiro Paradela, E., Papais Alvarenga, M., Ferreira Pereira, F., Vasconcelos, C.C., and Papais Alvarenga, R.M. Familial multiple sclerosis in a Brazilian sample: Is HLA-DR15 involved in susceptibility to the disease? 18001. 2019 J Neuroimmunol (330):

Concepts Keywords
Alleles HLA-DR15
Demographic HLA B7-DR15-DQ6
Genetic MHC Class II
Haplotype HLA-DR
HLA MS
Multiple Sclerosis
Risk Factor

Semantics

Type Source Name
gene UNIPROT PRG4
gene UNIPROT SEPT9
gene UNIPROT FN1
gene UNIPROT DNMT1
gene UNIPROT CD69
gene UNIPROT CD5L
disease MESH risk factor
gene UNIPROT HLA-DRB1
disease DOID multiple sclerosis
disease MESH multiple sclerosis
disease MESH Familial

Original Article

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