Longitudinal Association Between Depression and Inflammatory Markers: Results From the Netherlands Study of Depression and Anxiety.

Longitudinal Association Between Depression and Inflammatory Markers: Results From the Netherlands Study of Depression and Anxiety.

Publication date: May 15, 2019

While cross-sectional associations of inflammatory markers interleukin-6 (IL-6) and C-reactive protein with major depressive disorder are well established, evidence for longitudinal associations mostly comes from studies on depression symptoms, not diagnoses. This study examined cross-sectional and bidirectional longitudinal associations between depression diagnosis and symptoms in an adult sample over a 6-year period.

Data were obtained from the baseline (n = 2416) and 2- and 6-year follow-up assessments (n = 1925 and n = 1924, respectively) of the Netherlands Study of Depression and Anxiety. C-reactive protein and IL-6 were assessed at each wave, as were the Composite International Diagnostic Interview and Inventory of Depressive Symptomatology. Linear mixed models and generalized estimating equation models with a binomial distribution were used to study longitudinal associations between depression and inflammation and vice versa.

There was a consistent cross-sectional association between current depressive disorder (vs. no current disorder) and symptoms with IL-6 across all follow-up measurements (Cohen’s d = 0.06, p = .017; B = 0.029, SE = 0.011, p = .008). In longitudinal analyses, higher IL-6 levels predicted subsequent chronic course in those with a diagnosis at baseline in women but not in men (odds ratio = 1.13, 95% confidence interval = 1.04-1.23), and both depressive disorder and high severity predicted higher IL-6 levels at the subsequent follow-up (p values

In this longitudinal study, cross-sectional and bidirectional longitudinal associations were found between depression and IL-6 levels. This underlines the importance of targeting inflammation pathways in the treatment of major depressive disorder. IL-6 could be a potential marker for patient profiling in personalized medicine approaches.

Lamers, F., Milaneschi, Y., Smit, J.H., Schoevers, R.A., Wittenberg, G., and Penninx, B.W.J.H. Longitudinal Association Between Depression and Inflammatory Markers: Results From the Netherlands Study of Depression and Anxiety. 04594. 2019 Biol Psychiatry (85):10.

Concepts Keywords
Binomial Inflammation
Confidence Interval Interleukin 6
Cross Neuropsychology
Depression Major depressive disorder
Inflammation Abnormal psychology
Interleukin 6 Mood disorders
Longitudinal Study Neuroscience
Major Depressive Disorder Psychiatry
Netherlands Psychiatric diagnosis
Odds Ratio Branches of biology
Depression
Inflammation

Semantics

Type Source Name
gene UNIPROT CSRP1
gene UNIPROT CRP
gene UNIPROT ELL
disease MESH men
disease MESH depressive disorder
disease MESH inflammation
gene UNIPROT WASF1
disease MESH diagnoses
disease DOID major depressive disorder
disease MESH major depressive disorder
gene UNIPROT IL6
disease DOID Anxiety
disease MESH Anxiety
disease MESH Depression

Original Article

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