Mitochondrial Dysfunction in Parkinson’s Disease-Cause or Consequence?

Mitochondrial Dysfunction in Parkinson’s Disease-Cause or Consequence?

Publication date: May 11, 2019

James Parkinson first described the motor symptoms of the disease that took his name over 200 years ago. While our knowledge of many of the changes that occur in this condition has increased, it is still unknown what causes this neurodegeneration and why it only affects some individuals with advancing age. Here we review current literature to discuss whether the mitochondrial dysfunction we have detected in Parkinson’s disease is a pathogenic cause of neuronal loss or whether it is itself a consequence of dysfunction in other pathways. We examine research data from cases of idiopathic Parkinson’s with that from model systems and individuals with familial forms of the disease. Furthermore, we include data from healthy aged individuals to highlight that many of the changes described are also present with advancing age, though not normally in the presence of severe neurodegeneration. While a definitive answer to this question may still be just out of reach, it is clear that mitochondrial dysfunction sits prominently at the centre of the disease pathway that leads to catastrophic neuronal loss in those affected by this disease.

Chen, C., Turnbull, D.M., and Reeve, A.K. Mitochondrial Dysfunction in Parkinson’s Disease-Cause or Consequence? 20760. 2019 Biology (Basel) (8):2.

Concepts Keywords
Basel Mitochondrial disease
Consequence Mitochondrion
Idiopathic Parkinson’s disease
James Parkinson Senescence
Mitochondrial Neuroscience
Neurodegeneration Neurodegeneration
Parkinson Branches of biology
Pathogenic Mitochondrial dysfunction
Clear mitochondrial dysfunction

Semantics

Type Source Name
disease DOID neurodegenerative disease
disease MESH neurodegenerative disease
disease MESH familial
gene UNIPROT FBXW7

Original Article

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