Next Generation Networks: Featuring the Potential Role of Emerging Applications in Translational Oncology.

Next Generation Networks: Featuring the Potential Role of Emerging Applications in Translational Oncology.

Publication date: May 11, 2019

Nowadays, networks are pervasively used as examples of models suitable to mathematically represent and visualize the complexity of systems associated with many diseases, including cancer. In the cancer context, the concept of network entropy has guided many studies focused on comparing equilibrium to disequilibrium (i.e., perturbed) conditions. Since these conditions reflect both structural and dynamic properties of network interaction maps, the derived topological characterizations offer precious support to conduct cancer inference. Recent innovative directions have emerged in network medicine addressing especially experimental omics approaches integrated with a variety of other data, from molecular to clinical and also electronic records, bioimaging etc. This work considers a few theoretically relevant concepts likely to impact the future of applications in personalized/precision/translational oncology. The focus goes to specific properties of networks that are still not commonly utilized or studied in the oncological domain, and they are: controllability, synchronization and symmetry. The examples here provided take inspiration from the consideration of metastatic processes, especially their progression through stages and their hallmark characteristics. Casting these processes into computational frameworks and identifying network states with specific modular configurations may be extremely useful to interpret or even understand dysregulation patterns underlying cancer, and associated events (onset, progression) and disease phenotypes.

Open Access PDF

Capobianco, E. Next Generation Networks: Featuring the Potential Role of Emerging Applications in Translational Oncology. 04595. 2019 J Clin Med (8):5.

Concepts Keywords
Bioimaging Statistical randomness
Cancer Sync
Controllability Information theory
Disequilibrium Entropy
Entropy Natural sciences
Equilibrium Physics
Inference Asymmetry
Metastatic Physical sciences
Omics Metastasis
Oncological Systems diseases
Oncology Cancer
Phenotypes
Symmetry
Synchronization

Semantics

Type Source Name
gene UNIPROT TNIP1
gene UNIPROT MBNL1
gene UNIPROT INTU
pathway BSID Breast cancer
disease DOID Breast Cancer
disease MESH Breast Cancer
gene UNIPROT JTB
gene UNIPROT NR1I2
disease MESH large granular lymphocyte leukemia
gene UNIPROT MAGEE1
drug DRUGBANK (S)-Des-Me-Ampa
disease MESH stricture
disease DOID neuroblastoma
disease MESH neuroblastoma
gene UNIPROT DUOXA1
drug DRUGBANK Troleandomycin
pathway BSID Signal Transduction
gene UNIPROT UBXN11
disease DOID Boil
gene UNIPROT ADA2
gene UNIPROT PROC
gene UNIPROT APC
gene UNIPROT PIK3CA
disease DOID osteosarcoma
disease MESH osteosarcoma
gene UNIPROT BRD2
gene UNIPROT APPL1
gene UNIPROT OPRM1
gene UNIPROT NTSR1
gene UNIPROT SLC25A4
gene UNIPROT SLC25A6
gene UNIPROT MARK1
gene UNIPROT REM1
gene UNIPROT TCFL5
gene UNIPROT SFTPA1
gene UNIPROT LMLN
gene UNIPROT INVS
gene UNIPROT SOAT1
gene UNIPROT CAST
gene UNIPROT CD3EAP
gene UNIPROT ERC2
gene UNIPROT REST
disease DOID stomach adenocarcinoma
gene UNIPROT KIT
gene UNIPROT KDR
gene UNIPROT MAP3K1
gene UNIPROT PTEN
gene UNIPROT TP53
gene UNIPROT STAT5A
gene UNIPROT CDK2
gene UNIPROT NFKBIA
gene UNIPROT EGFR
gene UNIPROT ITGB1
gene UNIPROT PDGFRB
disease DOID Microphthalmia
disease MESH Microphthalmia
gene UNIPROT MITF
gene UNIPROT SOX10
pathway BSID Melanoma
disease DOID Melanoma
disease MESH Melanoma
pathway BSID Apoptosis
gene UNIPROT ESRRG
gene UNIPROT HSPD1
gene UNIPROT NR4A3
drug DRUGBANK Pentaerythritol tetranitrate
gene UNIPROT DEGS1
gene UNIPROT DYNLL1
gene UNIPROT NES
drug DRUGBANK Pirenzepine
gene UNIPROT ERBB2
gene UNIPROT FGFR4
gene UNIPROT THOP1
gene UNIPROT SGSM3
gene UNIPROT STUB1
gene UNIPROT TNFRSF11A
gene UNIPROT JUN
disease DOID leukemia
disease MESH leukemia
drug DRUGBANK L-Threonine
drug DRUGBANK Serine
disease MESH DNA damage
pathway BSID Cell Cycle
pathway BSID Cell cycle
gene UNIPROT SET
gene UNIPROT SSRP1
pathway BSID DNA Replication
gene UNIPROT APCS
gene UNIPROT SH2D1A
pathway BSID Translation
disease MESH development
drug DRUGBANK Isoxaflutole
disease MESH chromothripsis
gene UNIPROT TNFSF14
disease MESH genome stability
disease MESH repression
pathway BSID Metabolism
disease MESH inflammation
gene UNIPROT SLC22A3
gene UNIPROT ITK
disease MESH uncertainty
pathway BSID Histone Modifications
pathway BSID Histone modifications
pathway BSID Methylation
gene UNIPROT LITAF
disease MESH multi
disease MESH metastasis
pathway BSID Metabolic pathways
disease MESH communities
gene UNIPROT LARGE1
disease MESH carcinogenesis
disease MESH Multiple
gene UNIPROT CHL1
gene UNIPROT CEP55
gene UNIPROT ETV6
gene UNIPROT COL9A3
gene UNIPROT COMP
gene UNIPROT COL9A1
gene UNIPROT SCN8A
gene UNIPROT COL9A2
gene UNIPROT IMPACT
disease DOID cancer
disease MESH cancer

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