The association of rs703842 variants in CYP27B1 with multiple sclerosis susceptibility is influenced by the HLA-DRB1*15:01 allele in Slovaks.

The association of rs703842 variants in CYP27B1 with multiple sclerosis susceptibility is influenced by the HLA-DRB1*15:01 allele in Slovaks.

Publication date: May 15, 2019

In this study, we analysed the association of rs703842 in CYP27B1 gene with multiple sclerosis (MS) risk and disability progression in a group of 496 MS patients and 521 controls. For the first time in Central European Slovak population, we found the rs703842 allele C to be protective factor against MS development (p = 1.09 cD7 10). Moreover, the risky genotypes TT and TC were showed to be associated with an increased MS risk, and this was aggravated by the homozygous carriage of the HLA-DRB1*15:01 allele (OR = 2.82 vs. 4.86, p 

Cierny, D., Michalik, J., Dubovan, P., Skerenov’a, M., Javor, J., Kurca, E., Dobrota, D., and Lehotsk’y, J. The association of rs703842 variants in CYP27B1 with multiple sclerosis susceptibility is influenced by the HLA-DRB1*15:01 allele in Slovaks. 17998. 2019 J Neuroimmunol (330):

Concepts Keywords
Allele HLA-DR3
Disability HLA-DR4
Genotypes Medical specialties
HLA Anatomy
Homozygous Organ systems
Multiple Sclerosis HLA-DR
Slovak Sjögren syndrome
Slovaks Salivary gland pathology
Syndromes
RTT
MS

Semantics

Type Source Name
disease MESH development
gene UNIPROT HLA-DRB1
disease DOID multiple sclerosis
disease MESH multiple sclerosis
gene UNIPROT CYP27B1

Original Article

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