Protein Misfolding and ER Stress in Huntington’s Disease.

Protein Misfolding and ER Stress in Huntington’s Disease.

Publication date: Jan 15, 2019

Increasing evidence in recent years indicates that protein misfolding and aggregation, leading to ER stress, are central factors of pathogenicity in neurodegenerative diseases. This is particularly true in Huntington’s disease (HD), where in contrast with other disorders, the cause is monogenic. Mutant huntingtin interferes with many cellular processes, but the fact that modulation of ER stress and of the unfolded response pathways reduces the toxicity, places these mechanisms at the core and gives hope for potential therapeutic approaches. There is currently no effective treatment for HD and it has a fatal outcome a few years after the start of symptoms of cognitive and motor impairment. Here we will discuss recent findings that shed light on the mechanisms of protein misfolding and aggregation that give origin to ER stress in neurodegenerative diseases, focusing on Huntington’s disease, on the cellular response and on how to use this knowledge for possible therapeutic strategies.

Open Access PDF

Shacham, T., Sharma, N., and Lederkremer, G.Z. Protein Misfolding and ER Stress in Huntington’s Disease. 06490. 2019 Front Mol Biosci (6):

Concepts Keywords
Cognitive Proteostasis
Huntingtin Protein structure
Huntington MTOR
Misfolding Huntingtin
Modulation Senescence
Monogenic Neuroscience
Neurodegenerative Diseases Protein folding
Pathogenicity Neurodegeneration
Stress Branches of biology
Toxicity Neurological disorders
Huntington s disease


Type Source Name
disease MESH fatal outcome
pathway BSID Neurodegenerative Diseases
disease MESH neurodegenerative diseases

Original Article

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