Hemodynamics of cerebral veins analyzed by 2d and 4d flow mri and ultrasound in healthy volunteers and patients with multiple sclerosis.

Hemodynamics of cerebral veins analyzed by 2d and 4d flow mri and ultrasound in healthy volunteers and patients with multiple sclerosis.

Publication date: May 17, 2019

Hemodynamic alterations of extracranial veins are considered an etiologic factor in multiple sclerosis (MS). However, ultrasound and MRI studies could not confirm a pathophysiological link. Because of technical challenges using standard diagnostics, information about the involvement of superficial intracranial veins in proximity to the affected brain in MS is scarce.

To comprehensively investigate the hemodynamics of intracranial veins and of the venous outflow tract in MS patients and controls.

Prospective.

Twenty-eight patients with relapsing-remitting MS (EDSS1.9 +/- 1.1; range 0-3) and 41 healthy controls.

3T/2D phase-contrast and time-resolved 4D flow MRI, extra- and transcranial sonography.

Hemodynamics within the superficial and deep intracranial venous system and outflow tract including the internal, basal, and great cerebral vein, straight, superior sagittal, and transverse sinuses, internal jugular and vertebral veins. Sonography adhered to the chronic cerebrospinal venous insufficiency (CCSVI) criteria.

Multivariate repeated measure analysis of variance, Student’s two-sample t-test, chi-square, Fisher’s exact test; separate analysis of the entire cohort and 32 age- and sex-matched participants.

Multi- and univariate main effects of the factor group (MS patient vs. control) and its interactions with the factor vessel position (lower flow within dorsal superior sagittal sinus in MS, 3 +/- 1 ml/s vs. 3.8 +/- 1 ml/s; P

Consistent with previous studies focusing on extracranial hemodynamics, our comprehensive analysis of intracerebral venous blood flow did not reveal relevant differences between MS patients and controls. Level of Evidence 1. Technical Efficacy Stage 3. J. Magn. Reson. Imaging 2019.

Schuchardt, F.F., Kaller, C.P., Strecker, C., Lambeck, J., Wehrum, T., Hennemuth, A., Anastasopoulos, C., , Mader, and Harloff, A. Hemodynamics of cerebral veins analyzed by 2d and 4d flow mri and ultrasound in healthy volunteers and patients with multiple sclerosis. 18043. 2019 J Magn Reson Imaging.

Concepts Keywords
3T Ultrasound
Basal Mri
Brain Magnetic resonance imaging
Chi Square Superior sagittal sinus
Cohort Great cerebral vein
Dorsal Medical ultrasound
Etiologic Veins
Factor Group Multiple sclerosis
Gradient Cardiovascular system
Hemodynamics Angiology
Internal Jugular Medical specialties
MRI MS
Multiple Sclerosis MRI multiple sclerosis
Outflow
Pathophysiological
Sagittal
Sonography
Technical Standard
Time Resolved
Ultrasound
Univariate
Variance
Velocity
Venous Blood
Venous System

Semantics

Type Source Name
gene UNIPROT STS
drug DRUGBANK Sodium Tetradecyl Sulfate
drug DRUGBANK Flunarizine
drug DRUGBANK Sulodexide
disease MESH Multi
disease DOID venous insufficiency
disease MESH venous insufficiency
gene UNIPROT NECTIN4
disease DOID relapsing-remitting MS
disease DOID multiple sclerosis
disease MESH multiple sclerosis
gene UNIPROT CYREN

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