[The roles and regulation mechanism of transcription factor GATA6 in cardiovascular diseases].

[The roles and regulation mechanism of transcription factor GATA6 in cardiovascular diseases].

Publication date: May 20, 2019

The GATA transcription factor family consists of six members, GATA1 through GATA6, which play important roles in the regulation of cell growth and differentiation, cell survival, and maintenance of body functions. Current studies regarding GATA6 transcription factor confirm that GATA6 plays a crucial role in the differentiation, development, and function of the human heart. Genetic mutations of GATA6 are associated with a variety of congenital heart diseases, dysfunction of the cardiac conduction system causing various arrhythmias, coronary artery disease, and dilated and hypertrophic cardiomyopathies. The relationship between GATA6 and the human heart is also impacted by multiple other genes and interactions in the body. In this review, we summarize the research and current knowledge of the GATA6 transcription factor related to the human heart and multiple pathologies which provides understanding of its genetic basis to enable future personalized gene therapy and to promote the development and incorporation of basic research into clinical medicine.

Sun, Z.Q. and Yan, B. . 04636. 2019 Yi Chuan (41):5.

Concepts Keywords
Arrhythmias Cardiomyopathy
Cardiac Conduction System GATA1
Cardiomyopathies GATA transcription factor
Cardiovascular Diseases GATA6
Clinical Medicine Transcription factors
Congenital Branches of biology
Coronary Artery Disease Hypertrophic cardiomyopathies
Genetic
Hypertrophic
Pathologies
Transcription Factor

Semantics

Type Source Name
disease MESH multiple
disease MESH hypertrophic cardiomyopathies
disease DOID coronary artery disease
disease MESH coronary artery disease
disease MESH heart diseases
disease MESH congenital
disease MESH development
gene UNIPROT GATA1
gene UNIPROT QRSL1
disease MESH cardiovascular diseases
gene UNIPROT GATA6

Original Article

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