Reactivation of Ancient Viruses May Be Involved in MS Inflammatory Response, Study Says

Reactivation of Ancient Viruses May Be Involved in MS Inflammatory Response, Study Says

Publication date: May 22, 2019

A team of researchers from the Institut Pasteur in France found that these viral DNA sequences contain specific instructions that, once active, can control the activity of nearby genes involved in the body’s defense. Finally, after examining T-cells isolated from MS patients, the team discovered these ancient viral sequences were abnormally active in the vicinity of genes involved in the body’s immune response. -Our study shows that reactivation of ancient viruses does not correspond to an infectious phenomenon, but to a defense response of the body when faced with an acute inflammatory phenomenon,” leading to chronic excessive inflammation, Christian Muchardt, PhD, head of the epigenetic regulation unit at the Institut Pasteur, said in a press release.

Concepts Keywords
Autoimmune Diseases Human Endogenous Retrovirus-W
Brain Paleovirology
Christian Immune system
Chromatin Viruses
Dieldrin Endogenous retrovirus
Endogenous Retroviruses Microbiology
Enhancers Virology
Epigenetic Branches of biology
Evolution Molecular biology
Fossil Infection inflammation
France Inflammation
Genome However autoimmune diseases
HERV Acute inflammatory phenomenon
Heterochromatin Infection
Immune Response
Immune System
Infection
Inflammation
Institut Pasteur
Multiple Sclerosis
Pesticide
PhD
Stress
T Cells
Viral
Virus
Viruses

Semantics

Type Source Name
gene UNIPROT PDC
pathway BSID Release
pathway BSID Immune System
disease MESH inflammation
disease MESH infection
disease MESH autoimmune diseases
disease MESH multiple sclerosis
disease DOID multiple sclerosis

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