Publication date: May 22, 2019
A team of researchers from the Institut Pasteur in France found that these viral DNA sequences contain specific instructions that, once active, can control the activity of nearby genes involved in the body’s defense. Finally, after examining T-cells isolated from MS patients, the team discovered these ancient viral sequences were abnormally active in the vicinity of genes involved in the body’s immune response. -Our study shows that reactivation of ancient viruses does not correspond to an infectious phenomenon, but to a defense response of the body when faced with an acute inflammatory phenomenon,” leading to chronic excessive inflammation, Christian Muchardt, PhD, head of the epigenetic regulation unit at the Institut Pasteur, said in a press release.
- Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells.
- Scientists link ancient viruses to the chronic inflammation causing multiple sclerosis
- Multiple sclerosis: Discovery of a mechanism responsible for chronic inflammation