CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease.

CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease.

Publication date: May 29, 2019

CpG-related single nucleotide polymorphisms (CGS) have the potential to perturb DNA methylation; however, their effects on Alzheimer disease (AD) risk have not been evaluated systematically. We conducted a genome-wide association study using a sliding-window approach to measure the combined effects of CGSes on AD risk in a discovery sample of 24 European ancestry cohorts (12,181 cases, 12,601 controls) from the Alzheimer’s Disease Genetics Consortium (ADGC) and replication sample of seven European ancestry cohorts (7,554 cases, 27,382 controls) from the International Genomics of Alzheimer’s Project (IGAP). The potential functional relevance of significant associations was evaluated by analysis of methylation and expression levels in brain tissue of the Religious Orders Study and the Rush Memory and Aging Project (ROSMAP), and in whole blood of Framingham Heart Study participants (FHS). Genome-wide significant (p

Ma, Y., Jun, G.R., Chung, J., Zhang, X., Kunkle, B.W., Naj, A.C., White, C.C., Bennett, D.A., De Jager, P.L., Consortium, Alzheimer’s Disease. Genetics., Mayeux, R., Haines, J.L., Pericak-Vance, M.A., Schellenberg, G.D., Farrer, L.A., and Lunetta, K.L. CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease. 18145. 2019 Aging Cell.

Concepts Keywords
Alzheimer Branches of biology
Blood Genetics
Brain Epigenetics
CpG Methylation
Framingham
Genome
Methylation
Rush
Single Nucleotide Polymorphisms
Sliding Window
SNPs

Semantics

Type Source Name
pathway BSID Aging
disease MESH Aging
pathway BSID Methylation
disease DOID Alzheimer disease
disease MESH Alzheimer disease

Original Article

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