Effect of mesenchymal stem cells on glial cells population in cuprizone induced demyelination model.

Effect of mesenchymal stem cells on glial cells population in cuprizone induced demyelination model.

Publication date: Jun 01, 2019

Mesenchymal stem cells (MSCs) have a notable potential to modulate immune responses and protect the central nervous system (CNS), mostly by secreting factors that affect inflammation. MSCs have the ability to improve several autoimmune diseases in animal models including multiple sclerosis (MS). MS is a disease of the CNS among adult humans and it is characterized by demyelination, neuroinflammation and gliosis. In this study, we first induced chronic demyelination by cuprizone, followed by intraventricular injection of MSC. Our results showed that MSC significantly decreased microgliosis and astrocytosis by secreting cytokines that have neuroprotective activity including TGF-β and CX3CL1. Also, downregulation of IL-1β and TNF-α as inflammatory chemokines was seen along with decreased astrocytes and microglia activation. Finally, these results showed that trophic factors secreted by MSC can increase oligodendrocyte population and remyelination rate by reducing pro-inflammatory factors. These findings demonstrate that MSC could decrease inflammation, gliosis and demyelination with neuroprotective and immunomodulating properties in chronic cuprizone demyelination model. Therefore MSC transplantation can be considered as a suitable approach for enhancing myelination and reducing inflammation in diseases such as MS.

Barati, S., Kashani, I.R., Tahmasebi, F., Mehrabi, S., and Joghataei, M.T. Effect of mesenchymal stem cells on glial cells population in cuprizone induced demyelination model. 18151. 2019 Neuropeptides (75):

Concepts Keywords
Astrocytes Demyelination
Astrocytosis Chronic cuprizone demyelination
Autoimmune Diseases TNF inflammatory chemokines
Central Nervous System Chronic demyelination
Chemokines Inflammation gliosis demyelination
Cytokines MS
Demyelination Autoimmune diseases
Downregulation Neurology
Glial Branches of biology
Gliosis Organ systems
IL 1 Glial cells
Inflammation Nervous system
Mesenchymal Astrogliosis
Microglia Myelin
Multiple Sclerosis Neuroinflammation
Myelination Neuroprotection
Neuroprotective Remyelination
Oligodendrocyte Microglia
TNF Transplantation
Trophic

Semantics

Type Source Name
gene UNIPROT TNF
gene UNIPROT IL1B
gene UNIPROT CX3CL1
gene UNIPROT SLC25A37
gene UNIPROT MSC
disease MESH gliosis
disease DOID multiple sclerosis
disease MESH multiple sclerosis
disease MESH autoimmune diseases
disease MESH inflammation
disease MESH demyelination
drug DRUGBANK Mesenchymal Stem Cells

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