Factors associated with disease progression and viral replication in patients with chronic hepatitis B virus infection.

Factors associated with disease progression and viral replication in patients with chronic hepatitis B virus infection.

Publication date: Jun 01, 2019

Hepatitis B virus (HBV) infection remains a severe clinical concern in China. Of note, the progression of HBV infection varies between different populations. To identify the factors that influence the disease progression and prognosis, a total of 478 chronic HBV-infected patients were enrolled, and liver function parameters, HBV DNA levels and hepatic fibrosis indices were analyzed. First, the results demonstrated a significant difference in hepatitis B e antigen (HBeAg) expression between male and female patients (χ=4.061, P=0.044). Furthermore, when comparing either HBeAg-negative or -positive male and female patients, males exhibited a greater variation in HBV DNA levels. Although significant differences between male and female patients in certain abnormal ratios of liver function parameters were identified, a trend in the differences was observed in the HBeAg-negative and -positive groups. When considering age, the results of the present study confirmed that HBV DNA levels decreased with advanced age, and the values of the majority of biomarkers exhibited an evident decreasing trend with increasing age. In addition, it was demonstrated that all HBeAg seropositive patients had higher levels of hepatic fibrosis indexes and higher abnormal ratios of hepatic fibrosis values in their serum when compared with those of HBeAg seronegative patients, particularly with regard to serum IV collagen. The present results revealed that HBV DNA replication was closely associated with liver function; however, it was notable that in HBeAg-negative patients, the association between HBV DNA levels and liver function was particularly significant among subjects aged

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Jia, J., Li, Y., Wei, C., Guo, R., Xu, H., Jia, Y., Wu, Y., Li, Y., Wei, Z., Qi, X., Li, Z., and Gao, X. Factors associated with disease progression and viral replication in patients with chronic hepatitis B virus infection. 04702. 2019 Exp Ther Med (17):6.

Concepts Keywords
Antigen Liver
Biomarkers Viral hepatitis
China HBeAg
Chronic HBV RTT
Collagen Viral structural proteins
HBV Medicine
Hepatic Fibrosis Hepatitis B virus
Hepatitis Medical specialties
Infection Viruses
Liver Significant difference hepatitis
Prognosis
Seronegative
Seropositive
Serum
Viral Replication
Virus

Semantics

Type Source Name
pathway BSID DNA Replication
disease MESH fibrosis
disease MESH infection
pathway BSID Hepatitis B
disease DOID Hepatitis B
disease MESH Hepatitis B
disease MESH chronic hepatitis B virus infection
disease MESH disease progression

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