Searching for the origins of the depressive symptoms in Huntington’s disease

Searching for the origins of the depressive symptoms in Huntington’s disease

Publication date: Jun 01, 2019

An altered function of Cdk5 kinase — an essential enzyme in several cell signalling pathways — could explain the physiopathology of the depressive-like behaviour in Huntington’s disease, according to a pre-clinical study in which the University of Barcelona’s experts ScEDlvia GincE9s, VercF3nica Brito, Albert Giralt and Jordi Alberch, from the Faculty of Medicine and Health Sciences and the Institute of Neurosciences of the UB (UBNeuro) have taken part.

Regarding Huntington’s disease, Cdk5 kinase has a complex involvement in the apparition of cognitive dysfunctions — according to previous studies by the research team — since it is able to alter the expression and functionality of these receptors.

“Therefore, we considered whether alterations of Cdk5 kinase could be the main cause of depressive phenotypes in Huntington’s,” notes GincE9s, member of the Research Group of Physiopathology and Treatment of Neurodegenerative Disorders (UB-IDIBAPS).

New molecular pathways to fight depression in people with Huntington’s The results of this study showed that in murine models with the disease, Cdk5 shows a higher activity in two brain regions — the nucleus accumbens and the prefrontal cortex — that are associated with anxiety and depression processes.

“It would be necessary to avoid unwanted effects in other physiological pathways where this enzyme is active, and this would require defining which molecules the Cdk5 kinase acts on -in a non-functional manner to create the depressive-like phenotype,” comments lecturer ScEDlvia GincE9s.

Concepts Keywords
Anxiety Molecular neuroscience
Barcelona Proteins
Brain Cyclin-dependent kinase 5
Cognition Typical major depression
Cognitive Depression
Cytoskeleton Branches of biology
Dendritic Spine Cell cycle
Depression Neurotrophic factors
Dopaminergic Cell biology
Enzyme NMDA receptor
Hippocampus PPP1R1B
Huntington Protein families
Kinase Brain-derived neurotrophic factor
Memory
Monoamine
Murine
Nervous System
Neurodegenerative
Neurogenesis
NMDA Receptor
Nucleus Accumbens
Pathology
Pharmacological
Phenotype
Phenotypes
Physiology
Physiopathology
Prefrontal Cortex
Receptors
Serotonin
Serotoninergic
Signalling Pathway
Synaptic Plasticity

Semantics

Type Source Name
drug DRUGBANK Serotonin
disease MESH Neurodegenerative Disorders
disease MESH anxiety
disease DOID anxiety
gene UNIPROT PPP1R1B
pathway BSID Neurodegenerative Diseases
disease MESH depressive symptoms
gene UNIPROT CDK5
gene UNIPROT TNFSF14
gene UNIPROT SMIM10L2B
gene UNIPROT SMIM10L2A
disease MESH cognitive dysfunctions
gene UNIPROT IMPACT
gene UNIPROT PTPN5

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