Using stem cell-derived neurons in drug screening for neurological diseases.

Using stem cell-derived neurons in drug screening for neurological diseases.

Publication date: Jun 01, 2019

Induced pluripotent stem cells and their derivatives have become an important tool for researching disease mechanisms. It is hoped that they could be used to discover new therapies by providing the most reliable and relevant human in vitro disease models for drug discovery. This review will summarize recent efforts to use stem cell-derived neurons for drug screening. We also explain the current hurdles to using these cells for high-throughput pharmaceutical screening and developments that may help overcome these hurdles. Finally, we critically discuss whether induced pluripotent stem cell-derived neurons will come to fruition as a model that is regularly used to screen for drugs to treat neurological diseases.

Little, D., Ketteler, R., Gissen, P., and Devine, M.J. Using stem cell-derived neurons in drug screening for neurological diseases. 06512. 2019 Neurobiol Aging (78):

Concepts Keywords
Drug Discovery Drug screening
Neurological Diseases Drug discovery
Neurons Lorenz Studer
Pharmaceutical Stem-cell therapy
Pluripotent Developmental biology
Stem Cell Biotechnology
Throughput Cell biology
Induced stem cells
Stem cells
Branches of biology
Life sciences

Semantics

Type Source Name
disease MESH Motor neuron disease
disease DOID Motor neuron disease

Original Article

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