A pilot study on the efficacy of transcranial direct current stimulation applied to the pharyngeal motor cortex for dysphagia associated with brainstem involvement in multiple sclerosis.

A pilot study on the efficacy of transcranial direct current stimulation applied to the pharyngeal motor cortex for dysphagia associated with brainstem involvement in multiple sclerosis.

Publication date: Jun 01, 2019

we investigated the effect of anodal transcranial direct current stimulation (tDCS) applied over the pharyngeal motor area in dysphagia associated with multiple sclerosis (MS).

Eighteen MS patients with dysphagia associated with brainstem involvement were randomized to receive either “real” or “sham” tDCS.

The Penetration/Aspiration Scale (PAS).

changes in electromyographic (EMG) parameters and pharyngeal cortical motor evoked potentials (MEPs). Patients were evaluated at baseline (T), at the end of 5-session cycle of tDCS stimulations (T), after two (T), and four (T) weeks.

the PAS values were significantly lower in the active group than in “sham” group at T, and at T. Over the post-stimulation periods, PAS significantly improved only in the “real” group. As regards the secondary outcomes, we observed a statistically significant difference between the 2 groups only in the MEPs amplitude at T. The comparison between baseline and each of the post-stimulation times showed significant differences only of the “real” group across all the secondary parameters.

Our findings support a beneficial effect of anodal tDCS applied to the pharyngeal motor cortex in MS-associated dysphagia.

Considering its safety and efficacy, tDCS may represent an important resource in MS-associated dysphagia.

Restivo, D.A., Alfonsi, E., Casabona, A., Hamdy, S., Tassorelli, C., Panebianco, M., Marchese-Ragona, R., Quartarone, A., Centonze, D., Pavone, A., and Stampanoni Bassi, M. A pilot study on the efficacy of transcranial direct current stimulation applied to the pharyngeal motor cortex for dysphagia associated with brainstem involvement in multiple sclerosis. 18223. 2019 Clin Neurophysiol (130):6.

Concepts Keywords
Anodal Eighteen dysphagia
Brainstem Motor area dysphagia
Cortical MS
Dysphagia Branches of biology
Electromyographic Medicine
EMG Clinical medicine
Motor Cortex Neurostimulation
Motor Evoked Potentials Neurophysiology
Multiple Sclerosis Electrotherapy
PAS Medical devices
Pharyngeal Neurotechnology
TDCS Transcranial direct-current stimulation
Dysphagia
Swallowing
Evoked potential

Semantics

Type Source Name
gene UNIPROT SLC35G1
drug DRUGBANK Aminosalicylic Acid
disease DOID multiple sclerosis
disease MESH multiple sclerosis
disease MESH dysphagia
gene UNIPROT EGR3

Original Article

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