Atezolizumab in Patients With NSCLC or Advanced Solid Tumors Having Had Prior Treatment With a PD-1 Inhibitor

Atezolizumab in Patients With NSCLC or Advanced Solid Tumors Having Had Prior Treatment With a PD-1 Inhibitor

Publication date: Jun 06, 2019

This is a Phase II, two part trial (A and B), open label study of Atezolizumab for patients with non-small cell lung cancer (NSCLC) or an advanced solid tumor that has been previously treated with a PD-1 inhibitor (either nivolumab or pembrolizumab).

Concepts Keywords
Adrenal Insufficiency Solid tumor
Alanine Aminotransferase Dysfunction
Allergic Urinary tract infection
Allergy Idiopathic pulmonary fibrosis
Allogeneic Uncontrolled pleural effusion
Alopecia CNS metastases
ALT NSCLC
Aminotransferase Tumors
Anaphylactic Reactions Pre treatment tumor
ANC Pneumonia
Antibiotics Tumor
Antibodies Hamster ovary products
Antibody Compliance protocol
Anticonvulsant Autoimmune related hypothyroidism
Aspartate G psoriatic arthritis
AST Autoimmune immune deficiency
Asthma Solid tumors
Attenuated Vaccine Uncontrolled symptomatic hypercalcemia
Azathioprine G bronchiolitis
Barrier Method Cardiac disease
Bevacizumab Rash
Bilirubin Adrenal insufficiency
Biopsy Autoimmune diseases
Bisphosphonate Contraception
Breast Drainage
Bronchiolitis Obliterans Catheters
Carboplatin Antibiotics
Central Nervous System Chemotherapy
Chemotherapy Radiotherapy
Chimeric Surgery
Cisplatin Immunotherapy
Cohort Radiation
Computed Tomography Clinical medicine
Contraception Cancer treatments
Cooperative Group Antineoplastic drugs
COPD Breakthrough therapy
Correlation Monoclonal antibodies
Corticosteroid Bristol-Myers Squibb
Corticosteroids Atezolizumab
CPI Nivolumab
Creatinine Pembrolizumab
Creatinine Clearance Non-small-cell lung carcinoma
CT Scan Radiation
Cyclophosphamide Tomography
Diabetes Antibodies
Diabetes Mellitus Chemotherapy
Doublet Transplantation
Fibrosis Compliance protocol
Fludrocortisone
Glucose
Hamster
Hemoglobin
Histology
Hypercalcemia
Hypersensitivity
Idiopathic
Idiopathic Pulmonary Fibrosis
Immunohistochemistry
Immunosuppressant Medication
Immunosuppressive Medication
Immunotherapy
Informed Consent
Inhibitor
Interferon
Interleukin
Lactating
Ligand
Liver
Lung
Melanoma
Metastases
Methotrexate
Mineralocorticoids
Mismatch Repair
Mol
Monotherapy
MSI
Mutation
Neoantigen
Oral Hypoglycemic Agents
Organ
Orthostatic Hypotension
Ovary
Palliation
PCR
Platelets
Pneumonia
Pneumonitis
Port
Prophylactic
Pulmonary
Radiation
Radioisotopes
Radiotherapy
Receptor
Renal
Renal Carcinoma
Ribonucleic Acid
RNA Sequencing
RT
SCCHN
SCLC
Sequencing
Serum
Solid Tumor
Sperm
Squamous
Squamous Carcinoma
Strontium
Thalidomide
TMB
TNBC
TNF
Toxicity
Triple Negative
Triplet
Tumor
Urinary Tract Infection
Vaccine

Semantics

Type Source Name
gene UNIPROT CYGB
drug DRUGBANK Pembrolizumab
drug DRUGBANK Nivolumab
pathway BSID Non-small cell lung cancer
disease MESH non-small cell lung cancer
gene UNIPROT PDCD1
gene UNIPROT RPL17
disease MESH Tumors
disease DOID NSCLC
drug DRUGBANK Atezolizumab
disease DOID alopecia
disease MESH alopecia
disease DOID hypersensitivity
disease MESH hypersensitivity
disease MESH anaphylactic reactions
gene UNIPROT MRC1
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
disease DOID SCLC
gene UNIPROT XRCC1
disease DOID RCC
disease MESH Disease progression
gene UNIPROT ARMC9
gene UNIPROT AKR1A1
gene UNIPROT DUOXA1
drug DRUGBANK Creatinine
disease MESH renal
disease MESH Gilbert disease
gene UNIPROT SLC17A5
drug DRUGBANK L-Alanine
gene UNIPROT NR4A3
disease DOID hypercalcemia
disease MESH hypercalcemia
drug DRUGBANK Denosumab
disease DOID urinary tract infection
disease MESH urinary tract infection
disease MESH adrenal insufficiency
disease MESH orthostatic hypotension
pathway BSID Asthma
disease DOID asthma
disease MESH asthma
gene UNIPROT ARCN1
disease DOID chronic obstructive pulmonary disease
disease MESH chronic obstructive pulmonary disease
drug DRUGBANK Fludrocortisone
gene UNIPROT TNF
drug DRUGBANK Thalidomide
drug DRUGBANK Methotrexate
drug DRUGBANK Azathioprine
drug DRUGBANK Cyclophosphamide
gene UNIPROT IL2
disease MESH metastases
disease DOID central nervous system disease
disease MESH neurologic symptoms
disease MESH idiopathic pulmonary fibrosis
disease DOID idiopathic pulmonary fibrosis
disease MESH pneumonia
disease DOID pneumonia
disease MESH bronchiolitis obliterans
disease DOID bronchiolitis obliterans
disease MESH fibrosis
disease MESH diabetes mellitus
disease DOID diabetes mellitus
disease MESH fasting
drug DRUGBANK Dextrose unspecified form
drug DRUGBANK D-glucose
disease MESH cardiovascular disease
disease MESH myocardial infarction
disease DOID myocardial infarction
disease MESH cerebrovascular accident
disease DOID cerebrovascular accident
disease MESH arrhythmia
disease MESH unstable angina
disease DOID unstable angina
disease MESH ascites
drug DRUGBANK Calcium
disease MESH autoimmune disease
disease DOID autoimmune disease
disease MESH myasthenia gravis
disease DOID myasthenia gravis
disease MESH myositis
disease DOID myositis
disease MESH autoimmune hepatitis
disease DOID autoimmune hepatitis
disease MESH systemic lupus erythematosus
disease DOID systemic lupus erythematosus
pathway BSID Systemic lupus erythematosus
disease MESH rheumatoid arthritis
disease DOID rheumatoid arthritis
pathway BSID Rheumatoid arthritis
disease MESH inflammatory bowel disease
disease DOID inflammatory bowel disease
disease MESH antiphospholipid antibody syndrome
disease DOID antiphospholipid antibody syndrome
disease MESH Wegener granulomatosis
disease DOID Wegener granulomatosis
disease MESH syndrome
disease DOID syndrome
disease MESH multiple sclerosis
disease DOID multiple sclerosis
disease MESH hypothyroidism
disease DOID hypothyroidism
disease MESH eczema
disease DOID eczema
disease MESH psoriasis
disease DOID psoriasis
disease MESH lichen simplex chronicus
disease MESH vitiligo
disease DOID vitiligo
disease MESH psoriatic arthritis
disease DOID psoriatic arthritis
drug DRUGBANK Methionine
gene UNIPROT SLTM
gene UNIPROT MET
gene UNIPROT RNMT
disease DOID Rash
disease MESH infection
disease MESH complications
disease MESH bacteremia
disease MESH Diagnosis
disease MESH hepatitis B
disease DOID hepatitis B
pathway BSID Hepatitis B
disease MESH hepatitis C
disease DOID hepatitis C
pathway BSID Hepatitis C
disease MESH tuberculosis
disease DOID tuberculosis
pathway BSID Tuberculosis
disease MESH disease metabolic
disease MESH familial
gene UNIPROT NR4A2
gene UNIPROT ALG3
disease MESH Development

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