Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma

Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma

Publication date: Jun 07, 2019

Positive associations were observed for XPD 312 Asn/Asn versus Asp/Asp [odds ratio (OR) = 1. 5, 95% confidence interval (CI) 1. 2-1. 9] and XPD 751 Gln/Gln versus Lys/Lys (OR = 1. 4, 95% CI 1. 1-1. 7) genotypes and melanoma. The combined XPD Asn (A) 312 + Gln (C) 751 haplotype was significantly more frequent in cases (32%) compared with controls (29%) (P = 0. 003) and risk of melanoma increased significantly with one and two copies of the haplotype (ORs 1. 2, 95% CI 1. 0-1. 4, and 1. 6, 95% CI 1. 2-2. 0, trend P = 0. 002).

Concepts Keywords
Asn Branches of biology
Asp DNA repair
Australia Gene expression
Canada Cancer
Codon RTT
Confidence Interval Nucleotide excision repair
Etiology Protein biosynthesis
Genotypes ERCC6
Genotyping Melanoma
Gln Genetic code
Haplotype DNA repair-deficiency disorder
Italy Genotyping
Lys
Melanoma
Melanomas
Nucleotide Excision Repair
Odds Ratio
Polymorphisms
United States
XPD
XPF

Semantics

Type Source Name
pathway BSID Nucleotide Excision Repair
pathway BSID Nucleotide excision repair
disease MESH multiple
disease MESH melanoma
disease DOID melanoma
pathway BSID Melanoma
gene UNIPROT LARGE1
disease DOID XPD
gene UNIPROT ERCC2
drug DRUGBANK L-Asparagine
drug DRUGBANK L-Aspartic Acid
gene UNIPROT ATG5
gene UNIPROT A1CF
gene UNIPROT ASPM
gene UNIPROT ROPN1L
gene UNIPROT C3
gene UNIPROT ASPA
gene UNIPROT ASIP
drug DRUGBANK L-Lysine
gene UNIPROT RAD23B
disease DOID XPG
gene UNIPROT ERCC5
disease DOID XPC
gene UNIPROT XPC
disease DOID XPF
gene UNIPROT ERCC4
gene UNIPROT ERCC6

Original Article

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