Scientists recreate blood-brain barrier defect outside the body

Scientists recreate blood-brain barrier defect outside the body

Publication date: Jun 08, 2019

But in a new study, they recreated a critical brain component, the blood-brain barrier, that functioned as it would in the individual who provided the cells to make it.

Their achievement — detailed in a study published today in the peer-reviewed journal Cell Stem Cell — provides a new way to make discoveries about brain disorders and, potentially, predict which drugs will work best for an individual patient.

For their study, a team led by Cedars-Sinai investigators generated stem cells known as induced pluripotent stem cells, which can produce any type of cell, using an individual adult’s blood samples.

Significantly, when this blood-brain barrier was derived from cells of patients with Huntington’s disease or Allan-Herndon-Dudley syndrome, a rare congenital neurological disorder, the barrier malfunctioned in the same way that it does in patients with these diseases.

While scientists have created blood-brain barriers outside the body before, this study further advanced the science by using induced pluripotent stem cells to generate a functioning blood-brain barrier, inside an Organ-Chip, that displayed a characteristic defect of the individual patient’s disease.

The research combined the innovative stem cell science from investigators at Cedars-Sinai in Los Angeles with the advanced Organs-on-Chips technology of Emulate, Inc. in Boston.

Concepts Keywords
ALS Association Brain Neurological disorders
Amyotrophic Lateral Sclerosis ALS
Beer Sheva Brain disorders
Biomolecules Huntington s disease
Blood Branches of biology
Blood Brain Barrier Anatomy
Blood Vessel Brain
Boston Stem cells
Brain Emulate
California Cedars-Sinai Medical Center
Congenital Blood–brain barrier
Disclosure Human brain
Dudley Stroke
Gad Neurological disorder
Gatekeeper Stem cells
Genetic Regenerative Medicine
Herndon
Huntington
Israel
Los Angeles
Lou Gehrig
Microenvironment
Multicellular
Negev
Neurological Disorder
Neurons
Parkinson
Personalized Medicine
PhD
Physiology
Pluripotent
Postdoctoral Fellow
Precision Medicine
Sinai
Syndrome

Semantics

Type Source Name
gene UNIPROT SOD1
gene UNIPROT IGFALS
disease DOID Stroke
disease MESH Stroke
gene UNIPROT ESR1
gene UNIPROT ERAL1
disease MESH development
gene UNIPROT GTF2IRD1
gene UNIPROT CTSB
gene UNIPROT GAD1
gene UNIPROT PDC
disease MESH congenital
gene UNIPROT STUB1
drug DRUGBANK Nonoxynol-9
disease MESH brain disorders
gene UNIPROT BEST1
disease MESH Neurological disorders
disease MESH amyotrophic lateral sclerosis
disease DOID amyotrophic lateral sclerosis
gene UNIPROT SMIM10L2B
gene UNIPROT SMIM10L2A
drug DRUGBANK Sulodexide
disease MESH Allan-Herndon-Dudley syndrome
disease DOID Allan-Herndon-Dudley syndrome

Original Article

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