Publication date: Jun 08, 2019
But in a new study, they recreated a critical brain component, the blood-brain barrier, that functioned as it would in the individual who provided the cells to make it.
Their achievement — detailed in a study published today in the peer-reviewed journal Cell Stem Cell — provides a new way to make discoveries about brain disorders and, potentially, predict which drugs will work best for an individual patient.
For their study, a team led by Cedars-Sinai investigators generated stem cells known as induced pluripotent stem cells, which can produce any type of cell, using an individual adult’s blood samples.
Significantly, when this blood-brain barrier was derived from cells of patients with Huntington’s disease or Allan-Herndon-Dudley syndrome, a rare congenital neurological disorder, the barrier malfunctioned in the same way that it does in patients with these diseases.
While scientists have created blood-brain barriers outside the body before, this study further advanced the science by using induced pluripotent stem cells to generate a functioning blood-brain barrier, inside an Organ-Chip, that displayed a characteristic defect of the individual patient’s disease.
The research combined the innovative stem cell science from investigators at Cedars-Sinai in Los Angeles with the advanced Organs-on-Chips technology of Emulate, Inc. in Boston.
|disease||MESH||amyotrophic lateral sclerosis|
|disease||DOID||amyotrophic lateral sclerosis|