The Genomic Medicine Integrative Research Framework: A Conceptual Framework for Conducting Genomic Medicine Research.

The Genomic Medicine Integrative Research Framework: A Conceptual Framework for Conducting Genomic Medicine Research.

Publication date: Jun 06, 2019

Conceptual frameworks are useful in research because they can highlight priority research domains, inform decisions about interventions, identify outcomes and factors to measure, and display how factors might relate to each other to generate and test hypotheses. Discovery, translational, and implementation research are all critical to the overall mission of genomic medicine and prevention, but they have yet to be organized into a unified conceptual framework. To fill this gap, our diverse team collaborated to develop the Genomic Medicine Integrative Research (GMIR) Framework, a simple but comprehensive tool to aid the genomics community in developing research questions, strategies, and measures and in integrating genomic medicine and prevention into clinical practice. Here we present the GMIR Framework and its development, along with examples of its use for research development, demonstrating how we applied it to select and harmonize measures for use across diverse genomic medicine implementation projects. Researchers can utilize the GMIR Framework for their own research, collaborative investigations, and clinical implementation efforts; clinicians can use it to establish and evaluate programs; and all stakeholders can use it to help allocate resources and make sure that the full complexity of etiology is included in research and program design, development, and evaluation.

Horowitz, C.R., Orlando, L.A., Slavotinek, A.M., Peterson, J., Angelo, F., Biesecker, B., Bonham, V.L., Cameron, L.D., Fullerton, S.M., Gelb, B.D., Goddard, K.A.B., Hailu, B., Hart, R., Hindorff, L.A., Jarvik, G.P., Kaufman, D., Kenny, E.E., Knight, S.J., Koenig, B.A., Korf, B.R., Madden, E., McGuire, A.L., Ou, J., Wasserstein, M.P., Robinson, M., Leventhal, H., and Sanderson, S.C. The Genomic Medicine Integrative Research Framework: A Conceptual Framework for Conducting Genomic Medicine Research. 04755. 2019 Am J Hum Genet (104):6.

Concepts Keywords
Etiology

Semantics

Type Source Name
disease MESH development
disease MESH community
gene UNIPROT AICDA
gene UNIPROT LITAF
gene UNIPROT RASA1
gene UNIPROT RGS6

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *