Role of immune response, inflammation and tumor immune response-related cytokines/chemokines in melanoma progression.

Role of immune response, inflammation and tumor immune response-related cytokines/chemokines in melanoma progression.

Publication date: Jun 06, 2019

To investigate the role of tumor cytokines/chemokines in melanoma immune response, we estimated proportions of immune cell subsets in melanoma tumors from TCGA, followed by evaluation of association between cytokine/chemokine expression and these subsets. We then investigated association of immune cell subsets, chemokines, and cytokines with patient survival. Finally, we evaluated immune cell TIL score for correlation with melanoma patient outcome in a separate cohort. There was good agreement between RNA-seq estimation of T-cell subset with pathologist-determined TIL score. Expression levels of cytokines IL-12A, IFNG, IL-10, and chemokines CXCL9 and CXCL10 were positively correlated with PDCD1, CTLA-4, and CD8+ T cell subset, but negatively correlated with tumor purity (Bonferroni-corrected P

Fang, S., Xu, T., Xiong, M., Zhou, X., Wang, Y., Haydu, L.E., Ross, M.I., Gershenwald, J.E., Prieto, V.G., Cormier, J.N., Wargo, J., Sui, D., Wei, Q., Amos, C.I., and Lee, J.E. Role of immune response, inflammation and tumor immune response-related cytokines/chemokines in melanoma progression. 22926. 2019 J Invest Dermatol.

Concepts Keywords
CD8 CXCL10
Chemokine Melanoma
Chemokines Chemokine
Cohort CXCL9
Correlation Medicine
Cytokine Medical specialties
Cytokines Branches of biology
IFNG Cytokines
Immune Response Tumors
Inflammation Response inflammation tumor
Melanoma Tumor
Pathologist
RNA Seq
T Cell
Tumor

Semantics

Type Source Name
gene UNIPROT CTLA4
gene UNIPROT PDCD1
gene UNIPROT CXCL10
gene UNIPROT CXCL9
gene UNIPROT IL10
drug DRUGBANK Interleukin-10
gene UNIPROT IL12A
gene UNIPROT IFNG
gene UNIPROT TLR1
pathway BSID Melanoma
disease MESH melanoma
disease DOID melanoma
disease MESH tumor
disease MESH inflammation

Original Article

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