A review for the neuroprotective effects of andrographolide in the central nervous system.

A review for the neuroprotective effects of andrographolide in the central nervous system.

Publication date: Jun 07, 2019

Andrographolide is compound extracted from Andrographis paniculata (A. paniculata), a traditional herb that has been used in ancient China and other parts of eastern Asia to treat an array of disorders, such as cancer, rheumatoid arthritis, diarrhea, upper respiratory tract infection, and laryngitis, for a very long history. The mechanisms of action of andrographolide in disease prevention and/or therapy include anti-inflammation, anti-oxidative stress, anti-apoptosis, and/or pro-apoptosis. Pharmacodynamic studies have shown that andrographolide can cross the blood brain barrier and distribute into different brain regions, and therefore its pharmacological effects in the central nervous system (CNS) have begun to be revealed in recent years. For example, andrographolide has been reported to reduce brain infarct volume in several models of cerebral ischemia. In models of Alzheimer’s disease (AD), andrographolide not only reduces Aβ aggregation, but suppresses neuroinflammatory response and synaptic dysfunction, which could be evidenced by the reversal of microglia-mediated production of pro-inflammatory cytokines as well as AD-associated decreases in synaptic proteins, such as postsynaptic membrane dense substance-95. Andrographolide may also inhibit the onset and/or progression of Parkinson’s disease, multiple sclerosis, and surgery- or diabetes-induced cognitive impairment. Further, andrographolide has been shown to inhibit chronic stress-induced abnormalities in serum corticosterone levels, mood-associated behavior, and hippocampal neurogenesis, suggesting that andrographolide may have a potential to treat psychiatric disorders, such as anxiety and depression. In this review, we summarize and discuss the pharmacological effects of andrographolide in the CNS in hope of revealing more possibilities of andrographolide in disease prevention and/or therapy.

Lu, J., Ma, Y., Wu, J., Huang, H., Wang, X., Chen, Z., Chen, J., He, H., and Huang, C. A review for the neuroprotective effects of andrographolide in the central nervous system. 21105. 2019 Biomed Pharmacother (117):

Concepts Keywords
Alzheimer Anti inflammation
Anxiety Neuroinflammatory synaptic dysfunction
Apoptosis Chronic stress
Asia Surgery
Blood Brain Barrier Branches of biology
Brain Medical specialties
Cancer Glial cells
Central Nervous System Neurology
Cerebral Ischemia Microglia
China Neuroprotection
Chronic Stress Apoptosis
Cognitive Impairment Apoptosis
Corticosterone
Cross
Cytokines
Depression
Diabetes
Diarrhea
Herb
Hippocampal
Infarct
Inflammation
Laryngitis
Membrane
Microglia
Multiple Sclerosis
Neurogenesis
Neuroprotective
Oxidative Stress
Parkinson
Pharmacodynamic
Pharmacological
Postsynaptic
Psychiatric Disorders
Rheumatoid Arthritis
Serum
Synaptic

Semantics

Type Source Name
pathway BSID Apoptosis
disease MESH depression
disease DOID anxiety
disease MESH anxiety
drug DRUGBANK Corticosterone
disease MESH abnormalities
disease MESH cognitive impairment
disease DOID multiple sclerosis
disease MESH multiple sclerosis
disease MESH cerebral ischemia
pathway BSID Oxidative Stress
disease MESH oxidative stress
disease MESH inflammation
disease DOID laryngitis
disease MESH laryngitis
disease DOID diarrhea
pathway BSID Rheumatoid arthritis
disease DOID rheumatoid arthritis
disease MESH rheumatoid arthritis
disease DOID cancer
disease MESH cancer
drug DRUGBANK Andrographolide

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