Cerebrovascular reactivity and its correlation with age in patients with multiple sclerosis.

Cerebrovascular reactivity and its correlation with age in patients with multiple sclerosis.

Publication date: Jun 07, 2019

We assessed cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) within gray matter (GM), normal appearing white matter (NAWM) and white matter (WM) lesions in a group of multiple sclerosis (MS) patients. Furthermore, correlations between CBF, CVR and age were investigated. 31 MS patients and 25 healthy controls (HC) were examined on a 1.5 T MRI scanner, using pseudo-continuous arterial spin labeling MRI. MS vs HC CBF and CVR differences were assessed in GM regions of interest (i.e. resting state networks and vascular territories), and within WM. Correlations between CBF/CVR and age were then computed for MS and HC groups. Whereas no significant CBF and CVR differences were observed between MS and HC in any of the considered brain areas, significantly lower CBF was found in WM lesions with respect to NAWM (p 

Pelizzari, L., Lagan`a, M.M., Baglio, F., Bergsland, N., Cecconi, P., Viotti, S., Pugnetti, L., Nemni, R., Baselli, G., Clerici, M., and Mendozzi, L. Cerebrovascular reactivity and its correlation with age in patients with multiple sclerosis. 18277. 2019 Brain Imaging Behav.

Concepts Keywords
Brain Lesions
CBF MS
Cerebral Blood Flow Magnetic resonance imaging
Correlation Organ systems
Gray Matter Nervous system
MRI Nuclear magnetic resonance
MRI Scanner Arterial spin labelling
Multiple Sclerosis Neuroimaging
Spin Branches of biology
White Matter Cerebrovascular disease
Fluid-attenuated inversion recovery
White matter
MRI

Semantics

Type Source Name
gene UNIPROT SPIN1
gene UNIPROT GTF2I
gene UNIPROT CYREN
gene UNIPROT CEBPZ
disease MESH cerebral blood flow
disease DOID multiple sclerosis
disease MESH multiple sclerosis

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