Drug-drug Interaction Study to Evaluate the Effect of Omeprazole on CG5503 (Tapentadol)

Drug-drug Interaction Study to Evaluate the Effect of Omeprazole on CG5503 (Tapentadol)

Publication date: Jun 10, 2019

This was a single center, open-label, two-way crossover, drug-drug-interaction study to determine the effect of multiple dosing of omeprazole on 4 consecutive days on the pharmacokinetics of a single dose of an immediate-release capsule of CG5503 (tapentadol) in healthy participants.

Concepts Keywords
Alcohol Prohibitions restrictions protocol
Allergies HIV
Barrier Method Brain contusion
Beer Birth control
Benzodiazepines Surgery
Birth Control Hormone replacement therapy
Blood Drugs
Blood Donation Chemical compounds
Blood Pressure RTT
Brain Organic compounds
Breast Feeding Omeprazole
Caffeine Tapentadol
Center Open Drug interaction
Chemistry Diazepam
Chocolate Investigational New Drug
Clinical Laboratory Lorazepam
Clonazepam Heparin
Consciousness Heroin
Contraindicated Pharmacokinetics
Crossover Pharmacogenomic
Diastolic Prohibitions restrictions protocol
Diazepam
Drug Formulation
Drug Interaction
Electrocardiogram
Endocrine
Epilepsy
Excipients
Gastrointestinal
Genetic
Genetic Testing
Grapefruit
Grapefruit Juice
Hard Liquor
Hematology
Heparin
Hepatitis
Herbal Medication
HIV
Hormonal Contraceptives
Hormone Replacement Therapy
Human Chorionic Gonadotropin
Hypersensitivity
Ibuprofen
Immunodeficiency
Informed Consent
Intracranial Hematoma
Intrauterine Devices
Investigational Drug
Lock
Lorazepam
MAOIs
Menses
Methylxanthine
MmHg
Monoamine Oxidase Inhibitors
Naloxone
Neoplasm
Nonsteroidal
Norepinephrine
NSAIDS
Omeprazole
Opioid
Opioids
Ounce
Pharmacogenomic
Pharmacokinetics
Physical Examination
Postmenopausal
Pregnancy Test
Prescription Medication
Protocol
Pulmonary
Reuptake
Seizure Disorder
Sequelae
Serology
Serotonin
Serum
Seville Orange
Smoking
SNRIs
Sterilization
Stroke
Substance Abuse
Supine
Swallow
Systolic
Thromboembolic
Transient Ischemic Attack
Traumatic Brain Injury
Unconsciousness
Urinalysis
Urine
Virus
Vital Signs
Wine

Semantics

Type Source Name
pathway BSID Release
disease MESH multiple
drug DRUGBANK Tapentadol
drug DRUGBANK Omeprazole
disease MESH drug Interaction
gene UNIPROT FBN1
drug DRUGBANK Chorionic Gonadotropin (Human)
disease MESH electrocardiogram
gene UNIPROT NCKIPSD
disease MESH seizure disorder
disease DOID epilepsy
disease MESH stroke
disease DOID stroke
disease MESH transient ischemic attack
disease DOID transient ischemic attack
disease MESH brain neoplasm
disease DOID brain neoplasm
disease MESH hematoma
disease MESH unconsciousness
gene UNIPROT SLC35G1
disease MESH amnesia
disease DOID amnesia
disease MESH sequelae
disease MESH allergies
disease DOID hypersensitivity
drug DRUGBANK Naloxone
drug DRUGBANK Diazepam
drug DRUGBANK Clonazepam
drug DRUGBANK Lorazepam
drug DRUGBANK Heparin
disease MESH hepatitis B
disease DOID hepatitis B
pathway BSID Hepatitis B
disease MESH hepatitis C
disease DOID hepatitis C
pathway BSID Hepatitis C
disease MESH substance abuse
disease DOID substance abuse
drug DRUGBANK Ethanol
drug DRUGBANK Serotonin
gene UNIPROT OTC
drug DRUGBANK Ibuprofen
drug DRUGBANK Caffeine
gene UNIPROT AICDA
drug DRUGBANK Water
drug DRUGBANK Etoperidone

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