Invasive and non-invasive brain stimulation in Parkinson’s disease: Clinical effects and future perspectives.

Invasive and non-invasive brain stimulation in Parkinson’s disease: Clinical effects and future perspectives.

Publication date: Jun 10, 2019

In this review, we discuss the clinical and electrophysiological effects, and the future directions of invasive and non-invasive brain stimulations in Parkinson’s disease (PD). Deep brain stimulation (DBS) can improve motor symptoms in moderate to advanced PD. However, the optimal stimulation paradigm for non-motor symptoms, freezing of gait and the optimal timing of DBS are still under investigations. The findings of pathological oscillations and abnormal frequency to amplitude coupling provide models to develop adaptive DBS. Transcranial magnetic stimulation (TMS) revealed abnormal cortical excitability and plasticity in PD. Consecutive sessions of high frequency, repetitive TMS on the motor cortex showed promising results. Paired TMS and DBS at specific times provided a novel way to investigate PD pathophysiology and has potential as a future treatment. Transcranial direct current stimulation or transcranial alternating current stimulation with multifocal electrodes or at specific phases of oscillation are also potential future strategies. This article is protected by copyright. All rights reserved.

Chen, K.S. and Chen, R. Invasive and non-invasive brain stimulation in Parkinson’s disease: Clinical effects and future perspectives. 21112. 2019 Clin Pharmacol Ther.

Concepts Keywords
Amplitude Deep brain stimulation
Brain Medicine
Cortical Branches of biology
Coupling Clinical medicine
DBS Neurotechnology
Deep Brain Stimulation Electrotherapy
Electrophysiological Medical devices
Frequency Neurophysiology
Gait Neurostimulation
Motor Cortex Transcranial magnetic stimulation
Paradigm Brain stimulation
Parkinson Transcranial direct-current stimulation
Pathophysiology Deep brain stimulation
Plasticity
Transcranial Magnetic Stimulation

Semantics

Type Source Name
gene UNIPROT PYCARD
gene UNIPROT TYMS
drug DRUGBANK Tilmicosin
disease MESH gait
gene UNIPROT LRP2
gene UNIPROT MCF2L

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