Publication date: Jun 11, 2019
Israeli scientists at Ben-Gurion University of the Negev have recently been successful in duplicating a Blood-Brain Barrier outside the patient’s body using stem cells and microfluidic chips, producing a functioning copy of a patient’s brain structure and thus advancing personalized medicine.
However, the scientists duplicated a critical brain structure, the blood-brain barrier (BBB), which functions as it would in the individual who donated the cells to make it.
For their study, a team co-chaired by Dr. Gad Vatine, of BGU’s Regenerative Medicine and Stem Cell (RMSC) Research Center and the Department of Physiology and Cell Biology and by Clive N Svendsen, Ph. D of Cedars-Sinai Medical Center in Los Angeles, genetically manipulated blood cells collected from individual’s into stem cells, known as induced pluripotent stem cells, which can produce any type of cell in our bodies.
Although scientists have created blood-brain barriers outside the body before, the investigators said they believe this is the first time such a structure has been created from induced pluripotent stem cells that were derived from a patient, matched the patient’s DNA, and displayed a characteristic defect of the patient’s disease.
- Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications.
- Engineering Precision Medicine.
- Christopher C.W. Hughes, Ph.D. – Body-on-a-Chip: The New Frontier in Drug Discovery