Midbrain area for differentiating Parkinson’s disease from progressive supranuclear palsy.

Midbrain area for differentiating Parkinson’s disease from progressive supranuclear palsy.

Publication date: Jun 05, 2019

We aimed to investigate the values of midbrain area in diagnosing Parkinson’s Disease (PD) and progressive supranuclear palsy (PSP) by using transcranial sonography (TCS). Disease duration effect on brain sonographic findings could decrease the accuracy of TCS in PD and PSP patients. We reduced the disease duration effect on sonographic differences found between PD and PSP patients by using multivariate analysis.

Patients with clinical diagnosis of PSP and PD were recruited. We used SonoSite Edge II Ultrasound system to measure midbrain area, diameter of third ventricle and substantia nigra echogenicity. Diagnostic value of each measured area in sonography was estimated regarding its power for diagnosing PD or PSP. Independent sample t-test, Regression analysis and receiver operating characteristic (ROC) curve were performed using SPSS software.

Of 35 patients, 18 were PD and 17 PSP cases. The mean midbrain area was 4.86 +/- 0.71cm in PD patients and 3.61 +/- 0.85cm in those with PSP (P 

Ghourchian, S., Mousavi, A., Zamani, B., Shahidi, G., and Rohani, M. Midbrain area for differentiating Parkinson’s disease from progressive supranuclear palsy. 21106. 2019 Clin Neurol Neurosurg (183):

Concepts Keywords
Brain Spuranuclear palsy
Edge Progressive supranuclear palsy
Midbrain Medicine
Multivariate Analysis Health
Parkinson Clinical medicine
Progressive Cognitive disorders
PSP Rare diseases
Receiver Operating Characteristic Progressive supranuclear palsy
ROC Curve Syndromes
Sonography Medical ultrasound
SPSS Parkinson’s disease
Substantia Nigra PSP
Supranuclear Palsy Midbrain
TCS Ultrasound system
Ultrasound
Ventricle

Semantics

Type Source Name
disease MESH palsy
drug DRUGBANK Saquinavir
disease MESH diagnosis
gene UNIPROT TCOF1
gene UNIPROT MSMB
gene UNIPROT REG1A
gene UNIPROT PSPN
gene UNIPROT BPIFA2
gene UNIPROT RIDA
gene UNIPROT PSPH
gene UNIPROT STXBP3
disease MESH PSP
disease DOID progressive supranuclear palsy
disease MESH progressive supranuclear palsy

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