P2X7 receptor: A potential therapeutic target for autoimmune diseases.

P2X7 receptor: A potential therapeutic target for autoimmune diseases.

Publication date: Jun 07, 2019

P2X7 receptor (P2X7R), a distinct ligand-gated ion channel, is a member of purinergic type 2 receptor family with ubiquitous expression in human body. Previous studies have revealed a pivotal role of P2X7R in innate and adaptive immunity. Once activated, it will meditate some vital cascaded responses including the assembly of nucleotide-binding domain (NOD) like receptor protein 3 (NLRP3) inflammasome, non-classical secretion of IL-1β, modulation of cytokine-independent pathways in inflammation such as P2X7R- transglutaminase-2 (TG2) and P2X7R-cathepsin pathway, activation and regulation of T cells, etc. In fact, above responses have been identified to be involved in the development of autoimmunity, specifically, the NLRP3 inflammasome could promote inflammation in massive autoimmune diseases and TG2, as well as cathepsin may contribute to joint destruction and degeneration in inflammatory arthritis. Recently, numerous evidences further suggested the significance of P2X7R in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS), etc. In this review, we will succinctly discuss the biological characteristics and summarize the recent progress of the involvement of P2X7R in the development and pathogenesis of autoimmune diseases, as well as its clinical implications and therapeutic potential.

Cao, F., Hu, L.Q., , Yao, Hu, Y., Wang, D.G., Fan, Y.G., Pan, G.X., Tao, S.S., Zhang, Q., Pan, H.F., and Wu, G.C. P2X7 receptor: A potential therapeutic target for autoimmune diseases. 18282. 2019 Autoimmun Rev.

Concepts Keywords
Assembly Cathepsin C
Autoimmune Diseases Autoimmunity
Autoimmunity Inflammasome
Bowel NALP3
Cathepsin Cytokines
Cytokine RTT
Immunity Peptidase
Inflammasome Autoimmune diseases
Inflammation Cathepsins
Modulation Proteins
Multiple Sclerosis Medical specialties
NLRP3 Branches of biology
Nucleotide MS
Pathogenesis IBD
Purinergic Receptor
Rheumatoid Arthritis
Systemic Lupus Erythematosus


Type Source Name
disease MESH development
disease MESH inflammation
disease MESH autoimmune diseases
disease DOID inflammatory bowel disease
disease MESH inflammatory bowel disease
pathway BSID Rheumatoid arthritis
disease DOID rheumatoid arthritis
disease MESH rheumatoid arthritis
pathway BSID Systemic lupus erythematosus
disease DOID systemic lupus erythematosus
disease MESH systemic lupus erythematosus
disease DOID arthritis
disease MESH arthritis
pathway BSID The NLRP3 inflammasome
disease MESH autoimmunity
disease DOID multiple sclerosis
disease MESH multiple sclerosis
disease DOID IBD

Original Article

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