The gut microbiota perspective for interventions in MS.

The gut microbiota perspective for interventions in MS.

Publication date: Jun 06, 2019

The heritable genetic variation that explains phenotypic differences in a population fluctuates for different autoimmune disorders. Particularly in multiple sclerosis (MS) etiology, modest genetic and major environmental effects emerge. Increasingly recognized as a major environmentally shaped contributor to disease and treatment outcomes are gut microbiota. As discussed here, the observed impact of gut microbiome on MS pathophysiology, involves both quantitative and functional changes in composition, metabolism, gut permeability, homeostasis and modulation of the immune system. Although the first supplementary therapeutic interventions have been approached in general autoimmune disorders they are relatively cruder and a translation of knowledge from other pathologies is valuable but still required. Consequently initial therapeutic interventions with microbiota for autoimmune disorders could be correspondingly improved.

Zoledziewska, M. The gut microbiota perspective for interventions in MS. 18274. 2019 Autoimmun Rev.

Concepts Keywords
Autoimmune Disorders Autoimmune disorders
Etiology MS
Functional Composition Microbiota autoimmune disorders
Genetic Branches of biology
Genetic Variation Medical specialties
Gut Microbiota Microbiology
Gut Permeability Bacteriology
Heritable Environmental microbiology
Homeostasis Digestive system
Immune System Firmicutes
Metabolism Gut flora
Microbiome Human microbiota
Microbiota Akkermansia
Modulation Autoimmunity
Multiple Sclerosis Gastrointestinal tract
Pathologies
Pathophysiology
Phenotypic

Semantics

Type Source Name
disease MESH Experimental autoimmune encephalomyelitis
pathway BSID Translation
pathway BSID Immune System
pathway BSID Metabolism
gene UNIPROT IMPACT
disease DOID multiple sclerosis
disease MESH multiple sclerosis

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